文化大學機構典藏 CCUR:Item 987654321/36009
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/36009


    题名: Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia
    作者: Shih, YM (Shih, Yao-Ming)
    Shih, JM (Shih, Juey-Ming)
    Hou, YC (Hou, Yu-Chen)
    Yeh, CL (Yeh, Chiu-Li)
    Li, CC (Li, Cheng-Che)
    Yeh, SL (Yeh, Sung-Ling)
    贡献者: 食營系
    关键词: ACUTE LUNG INJURY
    PERIPHERAL ARTERY-DISEASE
    SKELETAL-MUSCLE
    REPERFUSION INJURY
    FATTY-ACIDS
    PROTECTS MICE
    MACROPHAGES
    MONOCYTES
    RECEPTOR
    CELLS
    日期: 2017
    上传时间: 2017-04-26 15:00:00 (UTC+8)
    摘要: This study investigated the effects of a fish oil-(FO-) based lipid emulsion on muscle leukocyte chemotaxis and inflammatory responses in a murine model of limb ischemia-reperfusion (IR) injury. Mice were assigned randomly to 1 sham (sham) group, 2 ischemic groups, and 2 IR groups. The sham group did not undergo the ischemic procedure. The mice assigned to the ischemic or IR groups were pretreated intraperitoneally with either saline or FO-based lipid emulsion for 3 consecutive days. The IR procedure was induced by applying a 4.5 oz orthodontic rubber band to the left thigh above the greater trochanter for 120 min and then cutting the band to allow reperfusion. The ischemic groups were sacrificed immediately while the IR groups were sacrificed 24 h after reperfusion. Blood, IR-injured gastrocnemius, and lung tissues were collected for analysis. The results showed that FO pretreatment suppressed the local and systemic expression of several IR-induced proinflammatory mediators. Also, the FO-pretreated group had lower blood Ly6C(hi)CCR2(hi) monocyte percentage and muscle M1/M2 ratio than the saline group at 24 h after reperfusion. These findings suggest that FOpretreatmentmay have a protective role in limb IR injury bymodulating the expression of proinflammatory mediators and regulating the polarization of macrophage.
    關聯: MEDIATORS OF INFLAMMATION 文獻號碼: 4929346
    显示于类别:[保健營養學系 ] 期刊論文

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