文化大學機構典藏 CCUR:Item 987654321/35985
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 46965/50831 (92%)
造访人次 : 12671015      在线人数 : 806
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CCUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/35985


    题名: IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease
    作者: Lin, JF (Lin, Jeng-Feng)
    Wu, S (Wu, Semon)
    Juang, JMJ (Juang, Jyh-Ming Jimmy)
    Chiang, FT (Chiang, Fu-Tien)
    Hsu, LA (Hsu, Lung-An)
    Teng, MS (Teng, Ming-Sheng)
    Cheng, ST (Cheng, Shih-Tsung)
    Huang, HL (Huang, Hsuan-Li)
    Sun, YC (Sun, Yu-Chen)
    Liu, PY (Liu, Pei-Yu)
    Ko, YL (Ko, Yu-Lin)
    贡献者: 生科系
    关键词: IL1RL1
    Single nucleotide polymorphism
    ST2
    Coronary artery disease
    Peripheral artery disease
    日期: 2017-02
    上传时间: 2017-04-19 16:16:28 (UTC+8)
    摘要: Background and aims: There are many IL1RL1 single nucleotide polymorphisms (SNP) significantly associated with circulating sST2 concentration. Little is known about the effects of IL1RL1 SNP on the outcome of cardiovascular disease. The aim of this study is to investigate whether IL1RL1 SNP can predict mortality.
    Methods: We enrolled 601 individuals receiving health examination, 532 patients with coronary artery disease (CAD), and 86 patients with peripheral artery disease (PAD). Genotyping for SNP rs950880 and rs13001325 was performed and sST2 level was measured. The primary endpoint was all-cause death. The secondary endpoints were cardiovascular death, myocardial infarction, hospitalization for heart failure, stroke, and amputation.
    Results: Individuals having rs950880 AA genotype all had rs13001325 TT genotype and tended to have lower sST2 levels in all 3 populations. Kaplan-Meier survival curves showed that patients with high sST2 level and rs950880 AA genotype had the lowest survival rate in presence of CAD (p < 0.001) and PAD (p = 0.007). In multivariable Cox regression analysis, the independent predictors of all-cause death were rs950880 AA homozygote (p = 0.018), age (p = 0.002), log sST2 level (p = 0.014), and log GDF-15 level (p - 0.017) in CAD patients. The independent predictor of all-cause death was rs950880-AA homozygote (p = 0.019) in PAD patients. There was no significant difference in secondary endpoints between rs950880 AA homozygote and C allele carriers.
    Conclusions: Individuals having rs950880 AA genotype also have rs13001325 TT genotype and tend to have lower sST2 levels. The rs950880 AA homozygote is an independent predictor of all-cause mortality in CAD and PAD patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
    關聯: ATHEROSCLEROSIS 卷: 257 頁碼: 71-77
    显示于类别:[生命科學系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML288检视/开启


    检视Licence

    在CCUR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈