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| 題名: | Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals |
| 作者: | Er, LK (Er, Leay-Kiaw)
Wu, S (Wu, Semon)
Chou, HH (Chou, Hsin-Hua)
Hsu, LA (Hsu, Lung -An)
Teng, MS (Teng, Ming-Sheng)
Sun, YC (Sun, Yu-Chen)
Ko, YL (Ko, Yu-Lin) |
| 貢獻者: | 生科系 |
| 關鍵詞: | LIPID-ACCUMULATION PRODUCT
VISCERAL ADIPOSITY INDEX
WAIST CIRCUMFERENCE
CARDIOMETABOLIC RISK
CARDIOVASCULAR RISK
METABOLIC SYNDROME
DIABETIC-PATIENTS
FASTING GLUCOSE
CLAMP TECHNIQUE
TISSUE |
| 日期: | 2016-03 |
| 上傳時間: | 2017-04-17 09:55:15 (UTC+8) |
| 摘要: | Background
Insulin resistance (IR) and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which contribute to the development of diabetes mellitus and cardiovascular diseases. We compared traditional lipid levels and ratios and combined them with fasting plasma glucose (FPG) levels or adiposity status for determining their efficiency as independent risk factors for IR.
Methods
We enrolled 511 Taiwanese individuals for the analysis. The clinical usefulness of various parameters-such as traditional lipid levels and ratios; visceral adiposity indicators, visceral adiposity index (VAI), and lipid accumulation product (LAP); the product of triglyceride (TG) and FPG (the TyG index); TyG with adiposity status (TyG-body mass index [BMI]) and TyG-waist circumference index [WC]); and adipokine levels and ratios-was analyzed to identify IR.
Results
For all lipid ratios, the TG/high-density lipoprotein cholesterol (HDL-C) ratio had the highest additional percentage of variation in the homeostasis model assessment of insulin resistance (HOMA-IR; 7.0% in total); for all variables of interest, TyG-BMI and leptin-adiponectin ratio (LAR) were strongly associated with HOMA-IR, with 16.6% and 23.2% of variability, respectively. A logistic regression analysis revealed similar patterns. A receiver operating characteristic (ROC) curve analysis indicated that TG/HDL-C was a more efficient IR discriminator than other lipid variables or ratios. The area under the ROC curve (AUC) for VAI (0.734) and TyG (0.708) was larger than that for TG/HDL-C (0.707). TyG-BMI and LAR had the largest AUC (0.801 and 0.801, respectively).
Conclusion TyG-BMI is a simple, powerful, and clinically useful surrogate marker for early identification of IR. |
| 關聯: | PLOS ONE 卷: 11 期: 3 文獻號碼: e0149731 |
| 顯示於類別: | [生命科學系] 期刊論文
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