Retrogenes in Preimplantation Embryo Development : A Unique Mode of Transcriptional Regulation

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Title:	Retrogenes in Preimplantation Embryo Development : A Unique Mode of Transcriptional Regulation 著床前胚發育期反轉錄基因表現調控研究
Authors:	黃秋容朱廣邦
Contributors:	動科系
Keywords:	胚發育甲基化著床前反轉錄基因 Embryo development Methylation Preimplantation Retrogene
Date:	2009-07
Issue Date:	2016-11-30 14:47:36 (UTC+8)
Abstract:	Our studies show that retrogenes are preferentially expressed in preimplantation embryos. These genes carry a short noncoding exon 1 that contributes directly to expression of the gene, and a second exon that contains the coding sequence without intron interruption. We show that preimplantation gene expression is first regulated by developmentally regulated transcription factors that target exon 1 and the solitary intron, followed by promoter hypermethylation on implantation and in adult tissues. An understanding of the mechanisms of gene expression during preimplantation development should have an impact on the understanding and treatment of spontaneous abortion and infertility.
Relation:	Journal of the Chinese Medical Association 72:7 2009.07[民98.07] 頁346-350+CA64
Appears in Collections:	[Department of Animal Science] journal articles

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