QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction

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Title:	QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction
Authors:	Lin, Jeng-Feng Hsu, Shun-Yi Wu, Semon Teng, Ming-Sheng Chou, Hsin-Hua Cheng, Shih-Tsung Wu, Tien-Yu Ko, Yu-Lin
Contributors:	生科系
Keywords:	QT interval brain natriuretic peptide acute myocardial infarction left ventricular remodeling
Date:	2015
Issue Date:	2016-03-10 15:13:09 (UTC+8)
Abstract:	Objectives: Heart-rate corrected QT (QTc) interval predicts cardiovascular mortality or all-cause mortality in the general population. Little is known about the best cut-off value of QTc interval for predicting clinical events in patients with ST-elevation myocardial infarction (STEMI). Methods: We enrolled 264 patients with STEMI who received measurement of QTc intervals at ER (QTc-ER), on day 2 (QTc-D2), and on day 3 (QTc-D3) of hospitalization. Clinical events, including all-cause death and readmission for heart failure, were followed for 2 years. Results: Prolonged QTc-ER, but not QTc-D2 or QTc-D3, well predicted clinical events with the best cut-off value of 445 ms. Patient with QTc-ER > 445 ms had lower left ventricular ejection fraction at baseline and at 6 months. Kaplan-Meier survival curves showed that the combination of QTc-ER > 445 ms and N-terminal pro-brain natriuretic peptide (NT-pro BNP) > 936 pg/mL was a strong predictor of clinical events (p<0.001). In multivariable Cox regression analysis, the independent predictors of death and heart failure were QTc-ER (p<0.001), log NT-proBNP (p<0.001), diabetes mellitus (p<0.001), history of stroke (p=0.001), and left ventricular end diastolic volume index (p<0.001). Conclusion: QTc-ER > 445 ms independently predicts clinical events in STEMI, providing incremental prognostic value to established clinical predictors and NT-proBNP.
Relation:	INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 卷: 12 期: 12 頁碼: 968-973
Appears in Collections:	[Department of Biology ] journal articles

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