Heatstroke Effect on Brain Heme Oxygenase-1 in Rats

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Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/32145

Title:	Heatstroke Effect on Brain Heme Oxygenase-1 in Rats
Authors:	Wen, Ya-Ting Liu, Tsung-Ta Lin, Yuh-Feng Chen, Chun-Chi Kung, Woon-Man Huang, Chi-Chang Lin, Tien-Jen Wang, Yuan-Hung Wei, Li
Contributors:	運健系
Keywords:	heat stroke heme oxygenase-1 cortical brain
Date:	2015
Issue Date:	2016-03-10 15:02:18 (UTC+8)
Abstract:	Exposure to high environmental temperature leading to increased core body temperature above 40 degrees C and central nervous system abnormalities such as convulsions, delirium, or coma is defined as heat stroke. Studies in humans and animals indicate that the heat shock responses of the host contribute to multiple organ injury and death during heat stroke. Heme oxygenase-1 (HO-1)-a stress-responsive enzyme that catabolizes heme into iron, carbon monoxide, and biliverdin-has an important role in the neuroprotective mechanism against ischemic stroke. Here, we investigated the role of endogenous HO-1 in heat-induced brain damage in rats. RT-PCR results revealed that levels of HO-1 mRNA peaked at 0 h after heat exposure and immunoblot analysis revealed that the maximal protein expression occurred at 1 h post-heat exposure. Subsequently, we detected the HO-1 expression in the cortical brain cells and revealed the neuronal cell morphology. In conclusion, HO-1 is a potent protective molecule against heat-induced brain damage. Manipulation of HO-1 may provide a potential therapeutic approach for heat-related diseases.
Relation:	INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 卷: 12 期: 9 頁碼: 737-741
Appears in Collections:	[Department of Exercise and Health Promotion] journal articles

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