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    Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/30872


    Title: Effect of Electrode Shape on Impedance of Single HeLa Cell: A COMSOL Simulation
    Authors: Wang, Min-Haw
    Chang, Wen-Hao
    Contributors: Dept Elect Engn
    Keywords: MICROFLUIDIC DEVICE
    SPECTROSCOPY
    ELECTROPORATION
    SIZE
    CHIP
    Date: 2015
    Issue Date: 2015-11-03 16:37:44 (UTC+8)
    Abstract: In disease prophylaxis, single cell inspection provides more detailed data compared to conventional examinations. At the individual cell level, the electrical properties of the cell are helpful for understanding the effects of cellular behavior. The electric field distribution affects the results of single cell impedance measurements whereas the electrode geometry affects the electric field distributions. Therefore, this study obtained numerical solutions by using the COMSOL multiphysics package to perform FEM simulations of the effects of electrode geometry on microfluidic devices. An equivalent circuit model incorporating the PBS solution, a pair of electrodes, and a cell is used to obtain the impedance of a single HeLa cell. Simulations indicated that the circle and parallel electrodes provide higher electric field strength compared to cross and standard electrodes at the same operating voltage. Additionally, increasing the operating voltage reduces the impedance magnitude of a single HeLa cell in all electrode shapes. Decreasing impedance magnitude of the single HeLa cell increases measurement sensitivity, but higher operational voltage will damage single HeLa cell.
    Relation: Biomed Research International,Volume 2015 (2015), Article ID 871603, 9 pages
    Appears in Collections:[Department of Electrical Engineering ] journal articles

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