Danggui Buxue Tang Inhibits 2,4-Dinitrochlorobenzene: Induced Atopic Dermatitis in Mice

CCUR > College of Environmental Planning & Bioresources > College of Agriculture > Graduate Institute of Biotechnology > journal articles > Item 987654321/30871

Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/30871

Title:	Danggui Buxue Tang Inhibits 2,4-Dinitrochlorobenzene: Induced Atopic Dermatitis in Mice
Authors:	Fang, Li-Wen Cheng, Chao-Chun Hwang, Tzann-Shun Huang, Wen-Chung Liou, Chian-Jiun Chen, Wen-Chyuan Wu, Shu-Ju
Contributors:	Grad Inst Biotechnol
Keywords:	CHINESE HERBAL MEDICINE TOPICAL APPLICATION SKIN-LESIONS MODEL MANAGEMENT EOSINOPHIL CHILDREN EXTRACT DISEASE RATS
Date:	2015
Issue Date:	2015-11-03 16:35:06 (UTC+8)
Abstract:	Danggui Buxue Tang (DBT) is a herbal decoction that has been used in Chinese medicine to enhance qi and blood circulation. Previously, we found that DBT can suppress allergy-related asthma in mice, leading us to hypothesize that DBT might ameliorate allergy disease. In this study, we evaluated whether DBT can attenuate atopic dermatitis (AD) symptoms and have an anti-inflammatory effect on AD-like mice. The dorsal skin of female mice was shaved and sensitized cutaneously (skin smear) with 1-chloro-2,4-dinitrobenzene. Mice were then given various doses of DBT from days 14 to 29 cutaneously. DBT treatment suppressed ear swelling and skin inflammation and decreased mast cell and eosinophil infiltration into skin and ear tissue. DBT also inhibited levels of IgE and Th2-associated cytokine levels in serum. These results demonstrate that cutaneous administration of DBT reduced the development of AD-like skin lesions in mice.
Relation:	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, Volume 2015 (2015), Article ID 672891, 10 pages
Appears in Collections:	[Graduate Institute of Biotechnology ] journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	373	View/Open

View Licence

Loading...