Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium

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Title:	Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium
Authors:	Wang, Hang Li, Tsung-Lin Hsia, Simon Su, I-Li Chan, Yi-Lin Wu, Chang-Jer
Contributors:	Dept Life Sci
Keywords:	muscle atrophy cachexia fish oil selenium chemotherapy
Date:	2015-04
Issue Date:	2015-10-23 14:47:44 (UTC+8)
Abstract:	Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle proteolysis, remained unclear. In this report, we demonstrated that tumor-induced myostatin in turn induced TNF-alpha, thus activating calcium-dependent and proteasomal protein degradation. Chemotherapy activated myostatin-mediated proteolysis and muscle atrophy by elevating IL-6. In tumor-bearing mice under chemotherapy, supplementation with fish oil and selenium prevented a rise in IL-6, TNF-alpha and myostatin and muscle atrophy. The findings presented here allow us to better understand the molecular basis of cancer cachexia and potentiate nutrition supplementation in future cancer chemotherapy.
Relation:	ONCOTARGET 卷: 6 期: 10 頁碼: 7758-7773
Appears in Collections:	[Department of Biology ] journal articles

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