文化大學機構典藏 CCUR:Item 987654321/30613
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    题名: Association of CDH13 Genotypes/Haplotypes with Circulating Adiponectin Levels, Metabolic Syndrome, and Related Metabolic Phenotypes: The Role of the Suppression Effect
    作者: Teng, Ming-Sheng
    Hsu, Lung-An
    Wu, Semon
    Sun, Yu-Chen
    Juan, Shu-Hui
    Ko, Yu-Lin
    贡献者: Dept Life Sci
    关键词: GENOME-WIDE ASSOCIATION
    INSULIN-RESISTANCE
    T-CADHERIN
    CARDIOVASCULAR-DISEASE
    DEPENDENT PATHWAY
    SENSITIVITY
    PROTEIN
    OBESITY
    GENE
    METAANALYSIS
    日期: 2015-04
    上传时间: 2015-10-23 14:44:11 (UTC+8)
    摘要: Objective

    Previous genome-wide association studies have indicated an association between CDH13 genotypes and adiponectin levels. In this study, we used mediation analysis to assess the statistical association between CDH13 locus variants and adiponectin levels, metabolic syndrome, and related metabolic phenotypes.

    Methods and results

    A sample population of 530 Taiwanese participants was enrolled. Four CDH13 gene variants in the promoter and intron 1 regions were genotyped. After adjustment for clinical covariates, the CDH13 genotypes/haplotypes exhibited an association with the adiponectin levels (lowest P = 1.95 x 10(-11) for rs4783244 and lowest P = 3.78 x 10(-13) for haplotype ATTT). Significant correlations were observed between the adiponectin levels and the various metabolic syndrome- related phenotypes (all P <= 0.005). After further adjustment for the adiponectin levels, participants with a minor allele of rs12051272 revealed a considerable association with a more favorable metabolic profile, including higher insulin sensitivity, highdensity lipoprotein cholesterol levels, lower diastolic blood pressure, circulating levels of fasting plasma glucose, and triglycerides, and as a lower risk of metabolic syndrome (all P < 0.05). The mediation analysis further revealed a suppression effect of the adiponectin levels on the association between CDH13 genotypes and metabolic syndrome and its related phenotypes (Sobel test; all P < 0.001).

    Conclusion

    The genetic polymorphisms at the CDH13 locus independently affect the adiponectin levels, whereas the adiponectin levels exhibit a suppressive effect on the association between CDH13 locus variants and various metabolic phenotypes and metabolic syndrome. In addition, these results provide further evidence of the association between the CDH13 gene variants and the risks of metabolic syndrome and atherosclerotic cardiovascular disease.
    關聯: PLOS ONE 卷: 10 期: 4 文獻號碼: e0122664
    显示于类别:[生命科學系] 期刊論文

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