文化大學機構典藏 CCUR:Item 987654321/30609
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    题名: Analgesic and Anti-Inflammatory Activities of Rosa taiwanensis Nakai in Mice
    作者: Tsai, Der-Shiang
    Huang, Mei-Hsuen
    Tsai, Jen-Chieh
    Chang, Yuan-Shuang
    Chiu, Yung-Jia
    Lin, Yen-Chang
    Wu, Lung-Yuan
    Peng, Wen-Huang
    贡献者: Grad Inst Biotechnol
    关键词: anti-inflammatory
    formalin test
    acetic acid writhing response
    lambda-carrageenan
    Rosa taiwanensis
    日期: 2015-05
    上传时间: 2015-10-23 14:20:23 (UTC+8)
    摘要: In this study, we evaluated the analgesic and anti-inflammatory activities of a 70% ethanol extract from Rosa taiwanensis Nakai (RTEtOH). The analgesic effect was determined using acetic acid-induced writhing response and formalin test. The anti-inflammatory activity was evaluated by lambda-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of RTEtOH was examined by measuring the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, IL-6, and malondialdehyde (MDA) in the paw edema tissue and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRd) in the liver tissue. The betulinic acid and oleanolic acid contents of RTEtOH were assayed by HPLC. The results showed that RTEtOH decreased the acetic acid-induced writhing responses (1.0 g/kg) and the late phase of the formalin-induced licking time (0.5 and 1.0 g/kg). In the anti-inflammatory models, RTEtOH (0.5 and 1.0 g/kg) reduced the paw edema at 3, 4, and 5 h after lambda-carrageenan administration. Moreover, the anti-inflammatory mechanisms might be due to the decreased levels of COX-2, TNF-alpha, IL-1 beta, and IL-6, as well as the inhibition of NO and MDA levels through increasing the activities of SOD, GPx, and GRd. The contents of two active compounds, betulinic acid and oleanolic acid, were quantitatively determined. This study demonstrated the analgesic and anti-inflammatory activities of RTEtOH and provided evidence to support its therapeutic use in inflammatory diseases.
    關聯: JOURNAL OF MEDICINAL FOOD 卷: 18 期: 5 頁碼: 592-600
    显示于类别:[生物科技研究所 ] 期刊論文

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