Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries

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題名:	Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries
作者:	Huang, Han-Ning Chan, Yi-Lin Hui, Cho-Fat Wu, Jen-Leih Wu, Chang-Jer Chen, Jyh-Yih
貢獻者:	Dept Life Sci
關鍵詞:	antimicrobial peptides tilapia piscidin 3 wound healing staphylococcus aureus
日期:	2015-05
上傳時間:	2015-10-23 13:51:18 (UTC+8)
摘要:	Antimicrobial peptides (AMPs), represent promising agents for new therapeutic approaches of infected wound treatment, on account of their antimicrobial and wound closure activities, and low potential for inducing resistance. However, therapeutic applications of these AMPs are limited by their toxicity and low stability in vivo. Previously, we reported that the 23 amino-acid designer peptide TP3 possessed antimicrobial activities. Here, we analyzed the wound closure activities of TP3 both and in vivo. TP3 at doses of up to 40 mu g/ml did not affect the viability of baby hamster kidney cells. Furthermore, TP3 was found to be highly effective at combating peritonitis and wound infection caused by MRSA in mouse models, without inducing adverse behavioral effects or liver or kidney toxicity. TP3 treatment increased survival by 100% at 8 days after infection, and accelerated the progression of proliferation, remodeling, and maturation of infected wounds. Taken together, our results indicate that TP3 enhances the rate of survival of mice infected with the bacterial pathogen MRSA through both antimicrobial and immunomodulatory effects. Overall, these results suggest that TP3 may be suitable for development as a novel topical agent for treatment of infected wounds.
關聯:	ONCOTARGET 卷: 6 期: 15 頁碼: 12955-12969 出版日期: MAY 30 2015
顯示於類別:	[生命科學系] 期刊論文

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