文化大學機構典藏 CCUR:Item 987654321/30601
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/30601


    题名: Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3'-Deoxy-3'-[F-18]-fluorothymidine PET
    作者: Chan, Pei-Chia
    Wu, Chun-Yi
    Chou, Lin-Shan
    Ho, Chung-Hsien
    Chang, Chi-Wei
    Chiou, Shih-Hwa
    Lin, Wuu-Jyh
    Chen, Fu-Du
    Chang, C.Allen
    Hwang, Jeng-Jong
    Liu, Ren-Shyan
    Wang, Hsin-Ell
    贡献者: Grad Inst Biotechnol
    关键词: [F-18]FLT
    HDACi
    Treatment response
    MicroPET
    Hepatocellular carcinoma
    日期: 2015-06
    上传时间: 2015-10-23 13:37:43 (UTC+8)
    摘要: This study employed 3'-deoxy-3'-[F-18]-fluorothymidine ([F-18]FLT) microPET scanning to assess the treatment response of histone deacetylase inhibitors (HDACi), e.g., N1-hydroxy-N8-phenyloctanediamide (SAHA) and its iodinated derivative ISAHA, in a hepatoma mouse model.

    The in vitro cytotoxicity of HDACi in various hepatoma cell lines was determined by MTT assay and flow cytometry. ISAHA and SAHA were used to treat HepG2 hepatoma xenograft-bearing mice. The treatment responses were characterized in terms of tumor burden, microPET imaging, and immunohistochemical staining of tumor sections.

    ISAHA effectively inhibited HepG2 hepatoma cell survival and tumor growth. A significantly reduced tumor uptake during HDACi treatment was noticed in [F-18]FLT microPET imaging, which was consistent with the findings in immunohistochemical staining.

    ISAHA can suppress tumor cell proliferation both in vitro and in vivo. [F-18]FLT PET is a promising modality for evaluating the in vivo therapeutic efficacy of HDACi at the early stage of treatment.
    關聯: MOLECULAR IMAGING AND BIOLOGY 卷: 17 期: 3 頁碼: 394-402
    显示于类别:[生物科技研究所 ] 期刊論文

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