文化大學機構典藏 CCUR:Item 987654321/30579
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    Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/30579


    Title: Associations between TRPV4 genotypes and body mass index in Taiwanese subjects
    Authors: Duan, De-Min
    Wu, Semon
    Hsu, Lung-An
    Teng, Ming-Sheng
    Lin, Jeng-Feng
    Sun, Yu-Chen
    Cheng, Ching-Feng
    Ko, Yu-Lin
    Contributors: Dept Life Sci
    Keywords: Body mass index
    Single nucleotide polymorphism
    Genetics
    Obesity
    Population studies
    Date: 2015-08
    Issue Date: 2015-10-20 16:09:15 (UTC+8)
    Abstract: Body weight regulation is influenced neuronally via the hypothalamus, which strongly expresses TRPV4. TRPV4 deficiency in mice confers resistance against diet-induced obesity. We investigated the association between TRPV4 gene variants and body mass index (BMI) in Taiwanese subjects. A sample population of 617 Taiwanese subjects was enrolled, and ten TRPV4 gene polymorphisms were selected and genotyped. After adjusting for clinical covariates, significant associations were observed between three studied polymorphisms and BMI using a dominant model (P = 4.83 x 10(-4), P = 1.17 x 10(-4), and P = 3.37 x 10(-4) for rs3742037, rs10735104, and rs3742035, respectively). Obesity as defined according to both the Asian and National Institutes of Health (NIH) criteria was significantly associated with rs10735104 (P = 0.003 and P = 0.037, respectively) in a dominant model. Genotypes at the TRPV4 locus independently affect BMI and obesity status in Taiwanese subjects. This association may broaden our understanding of the role of neuronal influence on body weight regulation. The regulation of TRPV4 channels in skeletal muscle and adipose tissue could also be a new therapeutic target for preventing the development of obesity.
    Relation: MOLECULAR GENETICS AND GENOMICS 卷: 290 期: 4 頁碼: 1357-1365
    Appears in Collections:[生命科學系] 期刊論文

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