文化大學機構典藏 CCUR:Item 987654321/2978
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    Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/2978


    Title: Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans
    Authors: Chiou W.F.
    Li S.Y.
    Ho L.K.
    Hsien M.L.
    Don M.J.
    Contributors: 化學系
    Keywords: cromakalim
    vasorelaxant activity
    ATP-sensitive K+ channels
    voltage-sensitive K+ channels
    Date: 2002
    Issue Date: 2009-12-11 09:33:09 (UTC+8)
    Abstract: A series of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans related to cromakalim (1) has been prepared and their vasorelaxant activities on isolated rat thoracic aorta precontracted with phenylephrine have been evaluated. The relaxant mechanism of 3a was found not through ATP-sensitive K+ channels as cromakalim, but through opening voltage-sensitive K+ channels. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
    Relation: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 37 Issue: 1 Pages: 69-75
    Appears in Collections:[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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