Potential role of tetrandrine in cancer therapy

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Title:	Potential role of tetrandrine in cancer therapy
Authors:	Chen YJ
Contributors:	化學系
Keywords:	tetrandrine apoptosis radiation-sensitizing agents radiation protection multiple drug resistance angiogenesis
Date:	2002
Issue Date:	2009-12-04 15:49:04 (UTC+8)
Abstract:	Tetrandrine, a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore, exhibits very broad pharmacological actions, including anti-tumor activity. The beneficial effects of tetrandrine on tumor cell cytotoxicity and radiosensitization, multidrug resistance, normal tissue radioprotection, and angiogenesis are most promising and deserve great attention. Tetrandfine has potential either as a tumoricidal agent or as an adjunct to chemotherapy and radiotherapy. To evaluate the potential clinical efficacy of tetrandrine for cancer therapy, more mechanism-based pharmacological, pharmacokinetic, and pharmacodynamic studies are required.
Relation:	ACTA PHARMACOLOGICA SINICA Volume: 23 Issue: 12 Pages: 1102-1106
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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