Solubilities of chlormezanone, metaxalone and methocarbamol in supercritical carbon dioxide

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Title:	Solubilities of chlormezanone, metaxalone and methocarbamol in supercritical carbon dioxide
Authors:	Lee, Chen-An Lee, Chen-An Ho, Sheau-Ling Chen, Yan-Ping
Contributors:	化學工程與材料工程學系暨奈米材料研究所
Keywords:	Solubility Active pharmaceutical ingredient Supercritical carbon dioxide Correlation
Date:	2014-01
Issue Date:	2015-01-28 10:09:45 (UTC+8)
Abstract:	The solubilities of three active pharmaceutical ingredients (APIs) in supercritical carbon dioxide were measured in this study using a semi-flow apparatus. These APIs are chlormezanone (C(11)H(12)C1NO(3)S), metaxalone (C12H15NO3) and methocarbamol (C11H15NO5) that are all used as skeletal muscle relaxants. The solubility data are reported for three isotherms at 308.2, 318.2 and 328.2 K, with the pressure range from 12 to 24 MPa. Most solubility data are within the range of 10(-6) to 10(-4) mole fraction for each API. The crossover phenomena were observed from the experimental results for all three systems. These solubility data satisfied the thermodynamic consistency tests. They were then correlated using three semi-empirical models. With the optimally fitted binary interaction parameters, satisfactory correlation agreement is presented for each binary mixture. (C) 2013 Elsevier B.V. All rights reserved.
Relation:	JOURNAL OF SUPERCRITICAL FLUIDS 卷: 85 卷: 85
Appears in Collections:	[Department of Chemical & Materials Engineering] journal articles

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