Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients

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Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/29282

Title:	Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients
Authors:	Hsieh, Chen-Hsi Shueng, Pei-Wei Wang, Li-Ying Liao, Li-Jen Lin, Yu-Chin Kuo, Ying-Shiung Lo, Wu-Chia Tseng, Chien-Fu Tien, Hui-Ju Chou, Hsiu-Ling
Contributors:	運教所
Keywords:	concurrent chemoradiation helical tomotherapy locoregional control rate oral cavity cancer trismus
Date:	2014
Issue Date:	2015-01-28 09:30:55 (UTC+8)
Abstract:	Background: The outcome of postoperative high-and intermediate-risk oral cavity cancer (OCC) patients receiving helical tomotherapy (HT) remains limited. Materials and methods: Between November 2006 and November 2012, 53 postoperative high-and intermediate-risk OCC patients treated with HT were enrolled. Results: The 4- year locoregional, local, and regional control rates were 66%, 76.4%, and 94.3%, respectively. The 4- year locoregional control rates of oral tongue and buccal mucosa cancer were 88.3% and 37.1%, respectively (P=0.012). Eleven (20.8%) patients experienced locoregional failure. In-field failure occurred in six of 53 (11.3%) in the primary area and three of 53 (5.7%) in the regional lymph-node area. No marginal failure was noted. Two of 53 (3.8%) experienced out-of-field failure. The rates of grade 3 dermatitis, mucositis, and dysphagia were 11%, 34%, and 13%, respectively. No grade 3 xerostomia was noted. Grade 2 xerostomia was 33% at month 6 and declined to 0 at month 48. A rate of 56% of grade 2 trismus at month 6 was noted, and declined to around 30% after 2 years. No grade 3 trismus was noted after 2 years. Conclusion: HT as a postoperative modality provided satisfying results, especially for xerostomia and trismus, and was impressive in high-and intermediate-risk OCC patients receiving postoperative HT.
Relation:	ONCOTARGETS AND THERAPY 卷: 7 頁碼: 405-414
Appears in Collections:	[Graduate Institute of Sport Coaching Science ] journal articles

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