MicroRNA-125a-3p expression in abdominal adipose tissues is associated with insulin signalling gene expressions in morbid obesity: observations in Taiwanese

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题名:	MicroRNA-125a-3p expression in abdominal adipose tissues is associated with insulin signalling gene expressions in morbid obesity: observations in Taiwanese
其它题名:	重度肥胖者腹腔脂肪組織microRNA-125a-3p的表現量與胰島素訊息傳遞相關基因表現相關：台灣人的觀察研究
作者:	Yeh, Chiu-Li Cheng, I-Chi Hou, Yu-Chen Wang, Weu Yeh, Sung-Ling
贡献者:	食品暨保健營養學系
关键词:	morbid obesity abdominal adipose tissue miR-125a-3p insulin signalling pathway insulin resistant
日期:	2014
上传时间:	2015-01-27 15:31:40 (UTC+8)
摘要:	Background: Micro (mi) RNAs have been found to play an important role in the regulation of adipogenesis and insulin sensitivity. However, associations between miRNA and insulin signalling-related gene expressions in abdominal adipose tissues in obese subjects remain unclear. Methods: We used a microarray platform to screen miRNA expressions in abdominal adipose tissues between genders in severely obese subjects and found that the top-ranking miRNA in abdominal mental adipose tissues was miRNA-125a-3p. MicroR-125a-3p and insulin signalling-related gene expressions in abdominal mental adipose tissues of all subjects (11 men and 10 women) were subsequently quantified by a real-time PCR. Also, associations of miR-125a-3p with insulin signalling-related gene expression and biochemical markers in obese subjects were analyzed by a linear regression analysis. Results: miR-125a-3p expressed by abdominal omental adipose tissues was much higher in obese men than women. No gender difference was observed in abdominal subcutaneous adipose tissues. Concomitant with high miR-125a-3p, c-Jun N-terminal kinase gene expression was also higher, whereas insulin receptor was lower in men than women. There were negative associations of miR-125a-3p with the insulin receptor and phosphatidylinositol 3-kinase expressions. Fasting plasma glucose and cholesterol levels were positively associated with miR-125a-3p expression. These associations were obvious in obese men but not women. Conclusion: Our results support the involvement of miR-125a-3p in regulating the insulin signalling pathway and imply that increased miR-125a-3p expression in omental adipose tissues may be a characteristic feature of insulin resistance in obese men.
關聯:	ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION 卷: 23 期: 2 頁碼: 331-337
显示于类别:	[保健營養學系 ] 期刊論文

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