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| 題名: | Synergistic effects of glycated chitosan with high-intensity focused ultrasound on suppression of metastases in a syngeneic breast tumor model |
| 作者: | Chen, Y-L
Wang, C-Y
Yang, F-Y
Wang, B-S
Chen, J.Y.
Lin, L-T
Leu, J-D
Chiu, S-J
Chen, F-D
Lee, Y-J
Chen, W.R. |
| 貢獻者: | 生物科技研究所 |
| 關鍵詞: | immunoadjuvant
high-intensity focused ultrasound
lung metastasis
breast cancer
epithelial-mesenchymal transition |
| 日期: | 2014-04 |
| 上傳時間: | 2015-01-27 11:16:32 (UTC+8) |
| 摘要: | Stimulation of the host immune system is crucial in cancer treatment. In particular, nonspecific immunotherapies, when combined with other traditional therapies such as radiation and chemotherapy, may induce immunity against primary and metastatic tumors. In this study, we demonstrate that a novel, non-toxic immunoadjuvant, glycated chitosan (GC), decreases the motility and invasion of mammalian breast cancer cells in vitro and in vivo. Lung metastatic ratios were reduced in 4T1 tumor-bearing mice when intratumoral GC injection was combined with local high-intensity focused ultrasound (HIFU) treatment. We postulate that this treatment modality stimulates the host immune system to combat cancer cells, as macrophage accumulation in tumor lesions was detected after GC-HIFU treatment. In addition, plasma collected from GC-HIFU-treated tumor-bearing mice exhibited tumor-specific cytotoxicity. We also investigated the effect of GC on epithelial-mesenchymal transition-related markers. Our results showed that GC decreased the expression of Twist-1 and Slug, proto-oncogenes commonly implicated in metastasis. Epithelial-cadherin, which is regulated by these genes, was also upregulated. Taken together, our current data suggest that GC alone can reduce cancer cell motility and invasion, whereas GC-HIFU treatment can induce immune responses to suppress tumor metastasis in vivo. |
| 關聯: | CELL DEATH & DISEASE 卷: 5 文獻號碼: e1178 |
| 顯示於類別: | [生物科技研究所 ] 期刊論文
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