English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 46867/50733 (92%)
造訪人次 : 11891272      線上人數 : 614
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    主頁登入上傳說明關於CCUR管理 到手機版


    請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/2922


    題名: Sepsis correlated with increased erythrocyte Na+ content and Na+-K+ pump activity
    作者: Hsieh CC
    Hwang TL
    Chen HM
    Chen MF
    Sun YF
    Lau YT
    貢獻者: 食營系
    關鍵詞: active transport
    erythrocyte
    Na+ pump
    ouabain binding
    sepsis
    日期: 2003
    上傳時間: 2009-11-30 11:57:56 (UTC+8)
    摘要: The aims of the present study were twofold: (1) simultaneous determinations of Na+ transport parameters of erythrocytes from 40 healthy donors and 28 septic patients as assessed by a score of severity of sepsis (SSS), and (2) examination of the correlation between the SSS and specific Na+ transport abnormalities. Erythrocytes were obtained and loaded with different ionic compositions and cellular Na+ contents before determination of the near-maximal Na+ pump rate (Vmax), the physiological extrusion rate of Na+ (v) and the number of ouabain-binding sites (Bmax). In erythrocytes from septic patients, the cellular Na+ content was 28% higher (p < 0.001), with no differences in water content compared to erythrocytes from healthy donors. This elevated Na+ content was accompanied by significantly higher values for Vmax (43%), v (24%) and Bmax (48%) of the Na+ pump in septic erythrocytes. Moreover, significant positive correlations existed between Vmax and SSS (p = 0.028) and between cellular Na+ content and SSS (p = 0.005). These data suggest that during sepsis, membrane alterations occur and result in an increased cellular Na+ content. Active Na+ transport (Vmax and v) was significantly stimulated, possibly as a consequence of a secondary response to the elevated Na+ of cells. Both cellular Na+ and Vmax correlated well with the severity of sepsis, suggesting that these altered transport parameters may reflect the progress of sepsis. Copyright (C) 2003 National Science Council, ROC and S. Karger AG, Basel.
    關聯: JOURNAL OF BIOMEDICAL SCIENCE Volume: 10 Issue: 4 Pages: 389-395
    顯示於類別:[保健營養學系 ] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbText406檢視/開啟


    在CCUR中所有的資料項目都受到原著作權保護.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋