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https://irlib.pccu.edu.tw/handle/987654321/29215
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| 題名: | Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease |
| 作者: | Wu, Semon
Hsu, Lung-An
Cheng, Shih-Tsung
Teng, Ming-Sheng
Yeh, Ching-Hua
Sun, Yu-Chen
Huang, Hsuan-Li
Ko, Yu-Lin |
| 貢獻者: | 生科系 |
| 關鍵詞: | circulating YKL-40 level
CHI3L1 gene variants
peripheral artery disease
association study
haplotype
risk factor |
| 日期: | 2014-12 |
| 上傳時間: | 2015-01-27 09:33:22 (UTC+8) |
| 摘要: | YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and long-term mortality of peripheral artery disease (PAD). Plasma YKL-40 concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic disease. Clinical parameters, CHI3L1 gene promoter variants and 18 biomarker levels were analyzed. Eighty-six PAD patients were further enrolled for analysis. Significant associations were found between CHI3L1 genotypes/haplotypes and YKL-40 levels for the health examination subjects (smallest p = 8.36 x 10(-7) for rs4950928 and smallest p = 1.72 x 10(-10) for haplotype TGG) and also for PAD patients. For the health examination subjects, circulating YKL-40 level, but not CHI3L1 gene variants, were positively associated with age, smoking, and circulating levels of triglyceride, lipocalin 2 and multiple inflammatory biomarkers and negatively associated with low-density-lipoprotein cholesterol levels. Circulating YKL-40 level is also significantly associated with the risk of PAD (p = 3.3 x 10(-23)). Circulating YKL40 level, but not CHI3L1 gene promoter variants, is associated with the risk of PAD in Taiwanese. The association of YKL-40 levels with multiple quantitative traits relating to the risk of PAD may provide a molecular basis linking YKL-40 to atherosclerotic cardiovascular disease. |
| 關聯: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 卷: 15 期: 12 頁碼: 22421-22437 |
| 顯示於類別: | [生命科學系] 期刊論文
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