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https://irlib.pccu.edu.tw/handle/987654321/29135
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| 题名: | The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats |
| 作者: | Phan, Nam Nhut
Wang, Chih-Yang
Lin, Yen-Chang |
| 贡献者: | 生科所 |
| 关键词: | Arsenic
Cardiac function
Hypertension
Ventricular hypertrophy |
| 日期: | 2014-10-03 |
| 上传时间: | 2015-01-20 10:32:26 (UTC+8) |
| 摘要: | Arsenic is a ubiquitous toxic compound that exists naturally in many sources such as soil, groundwater, and food; in which vast majority forms are arsenite (As3+) or arsenate (As5+). The mechanism of arsenic detoxification in humans still remains obscured. Epidemiologic studies documented that arsenic pollution caused black foot disease, cardiovascular diseases (hypertension, hypotension, cardiomyopathy), bladder cancer and skin cancer in many countries in which Taiwan is considered as high arsenic exposure country for long time ago. However, the effects of arsenic to cardiac functions still lacked of investigation while some studies mainly focus on inflammatory and cancer mechanisms. In the present study, we found cardiac hypertrophy signaling may be the most significant pathway for up regulated genes in arsenic exposed patients via bioinformatics approach. To verify our bioinformatics prediction, arsenic was fed orally to rats at different concentration based on previous studies in Taiwan. Using hemodynamic method as the main tool to measure the changes in blood pressure, left ventricular pressure and left ventricular contractility index, the findings suggest that highly exposure to arsenic lead to hypertension; elevated left ventricular diastolic pressure and alteration in cardiac contractility which are supposed to be the interaction between arsenic and cardiac nerves activity via the changing in calcium homeostasis. Collectively, based on our real-time PCR and western blot data strongly suggest that calcium homeostasis may also go through MEF2A, TNNI3, CAMKK2, CALM3 and cardiac hypertrophy relative signaling pathway. (C) 2014 Elsevier Ireland Ltd. All rights reserved. |
| 關聯: | TOXICOLOGY 卷: 324 頁碼: 123-135 |
| 显示于类别: | [生物科技研究所 ] 期刊論文
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