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    請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/2906


    題名: A study of the antioxidative and antimutagenic effects of Houttuynia cordata Thunb. Using an oxidized frying oil-fed model
    作者: Chen YY
    Liu JF
    Chen CM
    Chao PY
    Chang TJ
    貢獻者: 食營系
    關鍵詞: Houttuynia cordata Thunb
    polyphenol
    Ames test
    oxidized frying oil
    日期: 2003
    上傳時間: 2009-11-30 11:20:56 (UTC+8)
    摘要: The aims of this study were to evaluate the antioxidative effect of a traditional Taiwanese vegetable, Houttuynia cordata Thunb. (H. cordata), by subjecting rodents to oxidized frying oil-induced oxidative stress, and to examine the antimutagenic effects of H. cordata using the Ames test. Forty-eight Sprague-Dawley rats were fed a diet of 0, 2, or 5% H. cordata and 15% fresh oil or oxidized frying oil (OFO) for 28 d. Levels of polyphenol in the feces, plasma, and liver were determined. The LDL lag time, plasma total antioxidant status (TAS), and levels of thiobarbituric acid-reactive substances (TBARS) were used as antioxidative indices, and the protein carbonyl group was used as an oxidative index. The results showed that the polyphenol content decreased in the plasma and increased in the feces when administering OFO, and the apparent absorption of polyphenol also decreased. The polyphenol content in plasma increased when giving H. cordata. There was a higher polyphenol concentration in the water extracts of H. cordata than in the methanol extracts. The OFO-fed groups had higher plasma TBARS and hepatic protein carbonyl group concentrations and shorter LDL lag times than those of the control group. The total TAS was elevated and the LDL lag time was prolonged when fed with H. cordata. In addition, both water and methanol extracts of H. cordata had an antimutagenic effect on benzo(a)pyrene, aflatoxin B-1, and OFO, and showed a dose-dependent response using the Ames test. The antimutagenic ability of water extracts was higher than that of the methanol extracts. In conclusion, the polyphenol in H. cordata is easily absorbed and metabolized by rodents. H. cordata showed both antioxidative and antimutagenic properties under OFO feeding-induced oxidative stress.
    關聯: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY Volume: 49 Issue: 5 Pages: 327-333
    顯示於類別:[保健營養學系 ] 期刊論文

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