8週不同運動型態對中、老年人肌少症肥胖患者身體組成、肌力、合成激素及免疫反應之影響

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Title:	8週不同運動型態對中、老年人肌少症肥胖患者身體組成、肌力、合成激素及免疫反應之影響 Effects of Different Modes of Exercise for 8 Weeks on Body Composition, Muscular Strength, Anabolic Hormones and Immune Responses for Middle Aged and Elderly Adults with Sarcopenic Obesity
Authors:	吳慧君
Contributors:	體育學系
Keywords:	内臟脂肪體脂肪率睪固酮類胰島素生長因子肌肉
Date:	2014-08
Issue Date:	2014-10-23 11:26:35 (UTC+8)
Abstract:	本研究目的在探討不同運動型態之介入，對肌少症肥胖患者之身體組成、肌力表現、合成激素指標、血液發炎、抗發炎指標之影響情形。研究方法：以48位55歲以上具肌少症肥胖之中、老年人為研究對象。前測項目包含身體組成中之骨骼肌肉量指數（總骨骼肌肉重kg /體重kg x 100%)、内臟脂肪面積、體脂肪率；肌力表現（握力、背肌力、股四頭肌、股二頭肌）；合成激素指標 (testosterone、GH 與 IGF-1)；血液中發炎（CRP、IL-6 與 TNF-a )、抗發炎（IL-4、IL-10 )指標，均在四組訓練執行前完成。檢測完成後將研究對象隨機分成高強度阻力訓練組、有氧訓練組、合併訓練組及控制組，展開為期8週，每週2次、每次60分鐘之訓練。實驗過程於訓練中第5週、8 週訓練後一週及停止訓練後4週（亦即保留效果），檢測身體組成、肌力表現、合成激素及血液免疫反應指標。所得數據以混合設計雙因子變異數分析為統計方法，以a=.05為顯著水準。預期結果：透過本研究可預期瞭解不同運動型態對肌少症肥胖患者之身體組成、肌肉表現、合成激素指標、免疫反應指標之影響情形，以及停止訓練後4週之保留效果，未來或許可以做為改善中、老年人肌少症肥胖患者運動型態之參考。 The purpose of this study is to compare different modes of exercise training on body composition, muscular strength, anabolic hormones, pro-inflammatory and anti -inflammatory conditions. The subjects of this research will be 48 adults with sarcopenic obesity aged older than 55. All subjects will be tested for indicators of skeletal muscle mass index (total skeletal muscle mass (kg) / body weight (kg) x 100%), body fat percentage, visceral fat area, muscular strength (grip strength, back strength, quadriceps and biceps femoris strength), anabolic hormones (testosterone, GH, IGF-1), pro-inflammatory (C-reactive protein, IL-6, TNF-a), and anti -inflammatory (IL-4, IL-10). The 48 subjects will be randomly assigned to the high intensity resistance training (HIRT), aerobic training (AT), combination training (CT) and control (CON) groups during 8 weeks exercise training period for 60 minutes twice weekly. During exercise training period, the subjects will be tested for body composition , muscular strength, hormones, inflammation and anti -inflammatory in the 5th week, and 1 week as well as 4 weeks after training. All data will be analyzed using mixed-design two-way ANOVA. The a is set at .05. This research is expected to help the researcher understand the different modes of exercise training on body composition, muscular strength, hormones and immune response for patients with sarcopenic obesity, as well as the retention four weeks after training. The result may be available as optional reference on modes of exercise training for middle aged and elderly adults with sarcopenic obesity in the future.
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