| 摘要: | 本研究目的在瞭解罹患肌少症肥胖之老年人其診斷標準及日常身體活動量，與發炎指標、脆弱程度及跌倒風險之關係及預測力。方法是以21名65歲以上肌少症肥胖老年人為研究對象，平均年齡為72.2±5.73歲，身高158.1±9.10公分，體重69.2±10.04公斤。所有研究對象均完成填寫改良式CHAMPS身體活動問卷、VES-13老人脆弱量表及STRATIFY跌倒量表後，採集研究對象之肘前2 ml靜脈血。所得資料以皮爾森積差相關及多元逐步迴歸分析，進行肌少症肥胖者診斷指標及日常身體活動量與脆弱情形、跌倒危險因子、血液中發炎指標之相關及預測分析。結果發現，老年肌少症肥胖患者ASM/BW% 與IL-1β濃度、VES-13脆弱量表及STRATIFY老人跌倒量表分數達顯著負相關，解釋變異量分別達到23.2 、43.0及55.8 %，VFA也與IL-4濃度呈現負相關，但並未被選入預測變項；肌少症肥胖患者其日常身體活動量與IL-4濃度呈顯著正相關，解釋變異量達到38.1 %。本研究結論，肌少症肥胖患者四肢肌肉量指數越高，發炎體之IL-1β濃度、脆弱及跌倒風險越低，相反的，內臟脂肪越高IL-4濃度越低，但患者可透過增加日常身體活動量上調IL-4之抗發炎能力。因此，建議肌少症肥胖老年人應積極培養日常身體活動的習慣，尤其須融入漸進式阻力運動處方，藉以提升或維持肌肉量，以減緩其血液發炎、脆弱及跌倒的風險。
The purpose of the study was to understand the indicator of sarcopenic obesity and daily physical activity associated with inflammation, vulnerability, and fall risk in Sarcopenic Obesity Elderly. The method was based on Twenty-one sarcopenic obesity elderly were participated in this study (age: 72.2 ± 5.73 years old, height: 158.1 ± 9.10 cm, weight: 69.2 ± 10.04 kg). All subjects were completed to fill in the modified CHAMPS physical activity questionnaire, VES-13 vulnerability scale and STRATIFY fall scale, and two c.c. of blood samples of each subject were drawn from the antecubital vein. Data were analyzed by using Pearson Product-Moment Correlation and Regression Analysis. The results were shown that the ASM/BW% was significantly negative correlated with IL-1β, scale of VES-13 and STRATIFY, explained variation were 23.2, 43.0 and 55.8 %, VFA was also significantly negative correlated with IL-4 in sarcopenic obesity elderly, but not elected predictors; Daily physical activity was significantly correlated with IL-4 in sarcopenic obesity elderly, explained variation was 38.1 %. These results concluded that the higher appendicular skeletal muscle mass has the lower inflammasome of IL-1β, vulnerability and fall risk, conversely, the higher visceral fat has the lower IL-4, but the ability to upgrade anti-inflammatory IL-4 through increased daily physical activity. Therefore, it is suggested that the sarcopenic obesity elderly should positive training the habit of daily physical activity, in particular to integrate progressive resistance training, efforts to promote or maintain muscle mass to decrease the inflammation, vulnerability and fall risk. |
