| Title: | Antitumor agents. 239. isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza |
| Authors: | Wang XH;Bastow KF;Sun CM;Lin YL;Yu HJ;Don MJ;Wu TS;Nakamura S;Lee KH |
| Contributors: | 化學系 |
| Date: | 2004 |
| Issue Date: | 2009-11-23 10:53:49 (UTC+8) |
| Abstract: | Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate. |
| Relation: | JOURNAL OF MEDICINAL CHEMISTRY Volume: 47 Issue: 23 Pages: 5816-5819 |
| Appears in Collections: | [Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles
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