天然物 Ugonin C 和 Ugonin F 的合成研究

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题名:	天然物 Ugonin C 和 Ugonin F 的合成研究 Total synthesis of naturally occurring ugonin C and ugonin F
作者:	陳振維
贡献者:	化學系應用化學碩士班
关键词:	錫蘭七指蕨 Ugonin C Ugonin F
日期:	2014
上传时间:	2014-09-26 10:57:53 (UTC+8)
摘要:	Ugonin C和ugonin F為兩個黃酮類化合物都接有二氫呋喃部分，兩者皆由錫蘭七指蕨中被分離與確定出來，在先前的研究報導，天然或合成的黃酮類化合物具有許多藥理與生物活性，為了能得到較多的量與進一步探討ugonin C和ugonin F的生物活性，所以設計一有效的合成步驟來合成ugonin C和ugonin F。本論文中，3,5-bis(benzyloxy)phenol (4)作為起始物，4是參照文獻方法從1,3,5-trihydroxybenzene製備，從起始物經由五個步驟已成功的合成出含有二氫呋喃部分的關鍵中間產物acetophenone (9)，接下來依據設計的合成步驟，從9預計經由五個步驟可以完成ugonin C及ugonin F的全合成，同時可以合成其類似物，這些化合物將探討其生物活性。 Ugonin C and ugonin F, two flavonoids with a dihydrofuran ring, were isolated and characterized from Helminthostachys zeylanic. In previous studies, naturally occurring or synthetic flavonoids were found to show a variety of pharmaceutical and biological activities. In order to obtain more material for further studying the biological activity, the total synthesis of ugonin C and ugonin F was carried out. In this thesis, 3,5-bis(benzyloxy)phenol (4), prepared from 1,3,5-trihydroxybenzene according to the literature method, was chose to use as starting material. So far, the key intermediate acetophenone (9) with a dihydrofuran ring was successfully synthesized from 3,5-bis(benzyloxy)phenol in five steps. According to the proposed synthetic procedure, ugonin C and ugonin F will be synthesized from 9 in five steps. Analogues will be also synthesized. The biological activitives of all the synthesized compounds will be evaluated in the near future.
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