Platonin modulates differentiation and maturation of human monocyte-derived dendritic cells

CCUR > College of Kinesiology and Health > Graduate Institute of Sport Coaching Science > journal articles > Item 987654321/2816

Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/2816

Title:	Platonin modulates differentiation and maturation of human monocyte-derived dendritic cells
Authors:	Lee JJ Liao HF Yang YC Liu CL Chen YY Lin CP Chen YJ
Contributors:	運教所
Keywords:	platonin dendritic cell differentiation maturation CD80
Date:	2006
Issue Date:	2009-11-20 15:56:10 (UTC+8)
Abstract:	Platonin is a photosensitizer with NF-kappa B inhibitory activity that activates macrophages and suppresses lymphocyte response. In this study, we tested the effect of platonin on differentiation and maturation of human myeloid dendritic cells (DC) from CD14(+) monocytes. Triggering of DC differentiation by GM-CSF and IL-4 resulted in typical immature DCs that were further stimulated to maturation by combination of cytokines. When platonin (2 to 50 ng/mL) was added to the culture, the resulting DCs had thicker and blunter protruding projections, lower CD83 expression, greater CD80 expression, and less stimulatory activity on allogeneic naive CD4(+)CD45RA(+) T cells in terms of their proliferation and interferon-gamma production. This suggests that platonin redirects DC differentiation toward an intermediate stage of maturation, whereby the DCs have uniquely enhanced expression of CD80 which may confer some degree of immune tolerance. (c) 2005 Elsevier B.V. All rights reserved.
Relation:	INTERNATIONAL IMMUNOPHARMACOLOGY Volume: 6 Issue: 2 Pages: 287-293
Appears in Collections:	[Graduate Institute of Sport Coaching Science ] journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	Text	729	View/Open