文化大學機構典藏 CCUR:Item 987654321/2814
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    請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/2814


    題名: Renal ischemia/reperfusion injury inhibits differentiation of dendritic cells derived from bone marrow monocytes in rats
    作者: Wu CJ
    Sheu JR
    Chen HH
    Liao HF
    Yang YC
    Yang S
    Chen YJ
    貢獻者: 運教所
    關鍵詞: myeloid dendritic cells
    bone marrow-derived dendritic cells
    ischemia-reperfusion injury
    differentiation
    日期: 2006
    上傳時間: 2009-11-20 15:50:39 (UTC+8)
    摘要: Dendritic cells (DCs) are impacted by surgical injury, exercise, and other physiological stressors. This study aims to determine whether renal I/R injury affects 1) the differentiation of myeloid DCs from bone marrow monocytes (BMMos) and the maturation and activation state of these DCs and 2) DC infiltration of kidney. Sprague-Dawley rats were subjected to I/R injury or sham-operated. Creatinine clearance was monitored daily during the 14 d of reperfusion that followed the ischemic insult. At 2 and 14 d of reperfusion, the following were assessed 1) properties of BMMo-derived DCs (i.e., the amount of generated DCs, differentiation state markers [CD11c, CD80, CD86, and Ia], and functional state [MLR and amount of IL-12 produced]), and 2) the presence of DCs in the kidney. Numbers of BMMo-derived DCs were significantly decreased in the I/R injured group (compared with the sham-operated group) at 2 d but not 14 d. A comparison of the their functionality found mixed lymphocyte response [MLR] and IL-12 production were similar in the two groups at both time points. Also, immumohistochemistry showed infiltrating DCs in the outer medulla of the I/R injured kidney at 2 d but not 14 d of reperfusion. Thus, I/R stress reduces the number of DCs differentiated from BMMos but not the functional activity of these DCs. This decrease may reflect a stress-induced downshift in the capacity of BMMos to differentiate into DCs and a parallel upshift in the capacity of DCs to infiltrate the kidney. (c) 2005 Elsevier Inc. All fights reserved.
    關聯: LIFE SCIENCES Volume: 78 Issue: 10 Pages: 1121-1128
    顯示於類別:[運動教練研究所] 期刊論文

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