New lanostanes and naphthoquinones isolated from Antrodia salmonea and their antioxidative burst activity in human leukocytes

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Title:	New lanostanes and naphthoquinones isolated from Antrodia salmonea and their antioxidative burst activity in human leukocytes
Authors:	Shen CC Shen YC Wang YH Lin LC Don MJ Liou KT Wang WY Hou YC Chang TT
Contributors:	國術系
Keywords:	Polyporaceae Antrodia salmonea lanostane naphthoquinone anti-oxidative activity
Date:	2006
Issue Date:	2009-11-20 14:56:20 (UTC+8)
Abstract:	Four new compounds were isolated from the basidiomata of the fungus Antrodia salmonea, a newly identified species of Antrodia (Aphyllophorales) in Taiwan. These new compounds are named as lanosta-8,24-diene-3 beta,15 alpha,21-triol (1), 24-methylenelanost-8-ene-3 beta,15 alpha,21-triol (2), 2,3-dimethoxy-5-(2',5'-dimethoxy-3',4'-methylenedioxyphenyl)-7-methyl-[1,4]-naphthoquinone (3), and 2,3-dimethoxy-6-(2,5'-dimethoxy-3',4'-methylenedioxyphenyl)-7-methyl-[1,4]-naphthoquinone (4), respectively. Their structures were elucidated by spectroscopic methods. An in vitro cellular functional assay was performed to evaluate their anti-oxidative burst activity in human leukocytes. They showed inhibitory effects against phorbol 12-myristate-13-acetate (PMA), a direct protein kinase C activator, induced oxidative burst in neutrophils (PMN) and mononuclear cells (MNC) with 50% inhibitory concentration (IC50) ranging from 3.5 to 25.8 mu M. The potency order of these compounds in PMA-activated leukocytes was as 1 > 3 > 4 > 2. They were relatively less effective in formyl-Met-Leu-Phe (fMLP), a G-protein coupled receptor agonist, induced oxidative burst, except for compounds 3 and 4 in fMLP-activated PMN. These results indicated that three (1, 3, and 4) of these four newly identified compounds displayed antioxidative effect in human leukocytes with different potency and might confer anti-inflammatory activity to these drugs.
Relation:	PLANTA MEDICA Volume: 72 Issue: 3 Pages: 199-203
Appears in Collections:	[Department of Chinese Martial Arts] journal articles

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