Concurrent cisplatin-based chemoradiation for cervical carcinoma: Tumor response, toxicity, and serum cytokine profiles

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Title:	Concurrent cisplatin-based chemoradiation for cervical carcinoma: Tumor response, toxicity, and serum cytokine profiles
Authors:	Yang YC Wang KL Su TH Liao HF Wu MH Chen TC Huang MC Chen YJ
Contributors:	運教所
Keywords:	chemoradiation cervical cancer TGF-beta 1 G-CSF IL-6 VEGF
Date:	2006
Issue Date:	2009-11-20 13:49:58 (UTC+8)
Abstract:	Purpose . To evaluate the relation between tumor response, treatment toxicity, and serum cytokine profiles in patients with cervical cancer receiving cisplatin-based chemoradiation. Patients and Methods . Forty-two patients with cervical carcinoma receiving chemoradiation were recruited. Hemogram, biochemistry profile, cytokine levels, tumor size, and toxicity were assessed weekly. Results . The absolute neutrophil count decreased accompanied by an increase in serum levels of G-CSF during chemoradiation. The sudden elevation of serum TGF-beta 1 and VEGF levels after the first fraction of brachytherapy accompanied with the development of greater radiation therapy (RT) morbidity. Lower pretreatment TGF-beta 1 and VEGF levels are associated with tumor response to chemoradiation. Conclusion . The serial changes in serum cytokines during chemoradiation may correlate with tumor regression and treatment morbidity.
Relation:	CANCER INVESTIGATION Volume: 24 Issue: 4 Pages: 390-395
Appears in Collections:	[Graduate Institute of Sport Coaching Science ] journal articles

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