拉電子基取代之8,8-dicyanoheptafulvene和給電子基不對稱“單”取代之6-(4-methoxyphenyl)fulvene在氯仿迴流下進行[m+n]環化加成反應之研究

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Title:	拉電子基取代之8,8-dicyanoheptafulvene和給電子基不對稱“單”取代之6-(4-methoxyphenyl)fulvene在氯仿迴流下進行[m+n]環化加成反應之研究
Authors:	陳怡婷
Contributors:	應用化學研究所
Keywords:	環化加成反應立體選擇性催化劑位置選擇性位向選擇性生成物反應性 Periselectivity Diastereoselectivity Regioselectivity
Date:	2006
Issue Date:	2014-06-24 16:05:15 (UTC+8)
Abstract:	本論文主要在討論有關於拉電子基取代之6-(4-methoxyphenyl) fulvene和給電子基不對稱“單”取代在8,8-dicyanoheptafulvene為催化劑下加熱進行 [m+n] 環化加成反應之研究;對其進行環化加成反應之相互之間的反應性、立體選擇性（ Diastereoselectivity ）、位置選擇性（ Periselectivity ）和位向選擇性（Regioselectivity），有進一步徹底而詳細的研究探討。實驗結果顯示，在室溫的溫和反應條件下，8,8-dicyanoheptafulvene和給電子基不對稱單取代之 6-(4-methoxyphenyl) fulvene 反應，則會顯示出百分之百之endo 立體選擇性和反向（anti）位向選擇性與不錯之位置選擇性，進行〔6+4〕環化加成反應得到反向（anti）-endo-〔6+4〕環化加成生成物 23n / 23n’（1:1）。 The investigation of this research involves the synthesis and intermolecular [m+n] cycloadditions of the unsymmetrically electron-rich 6-monosubstituted 6-(4-methoxyphenyl)fulvene with 8,8-dicyaoheptafulvene ; designed to establish the experimental analyses of the reactivity, diastereoselectivity, periselectivity, and regioselectivity of these cycloadditions. The cycloaddition reaction of 8,8-dicyanoheptafulvene with 6-(4-methoxyphenyl)fulvene at room temperature gave the anti-endo-[6+4] cycloadducts 23n/23n’(1:1 ratio) and. The present results show that these [6+4] cycloaddition reactions took place with exclusive endo diastereoselectivity and anti regioselectivity. Good periselectivity was also observed.
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] thesis

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