幾丁聚醣3D多孔材之製造與其物化性之探討

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題名:	幾丁聚醣3D多孔材之製造與其物化性之探討 The study of preparation and characterization of three-dimensionalchitosan porous scaffolds
作者:	林育彥
貢獻者:	材料科學與奈米科技研究所
關鍵詞:	幾丁聚醣 3D多孔材多孔 chitosan Three-dimensional porous
日期:	2006
上傳時間:	2014-06-17 15:46:04 (UTC+8)
摘要:	3D多孔材應用廣泛而且其孔隙大小及孔隙率直接影響材料的物化性及生物相容性。目前3D多孔材多以PLA為原料，其取之方便，但PLA分解方面所需時間較長。天然高分子材料分解方面不需要很長的時間，所以本研究以天然高分子材料為主要原料，幾丁聚醣就是為其中之ㄧ。本研究是經改變幾丁聚醣濃度與控制攪拌轉速、加工溫度等之條件製造出不同孔隙大小及孔隙率之多孔材。所得之樣本以SEM確認其成形性、以吸水率標準測其支架吸水的多寡、樣本放置於不同pH溶液探討其物性、以FTIR鑑定其結構的變化、以應力-應變分析探討其機械性質、以體外酵素分解分析其生物相容性。其實驗結果顯示幾丁聚醣添加濃度在2%，NaOH在5% 可以得到較佳成形的樣本。均質機攪拌速度越快會使樣本孔隙大小及孔隙率越小，但是轉速達4000rpm後其孔隙大小及孔隙率變化不大。若改變樣本加工溫度，60℃之後會破壞樣本之結構，溫度到達80℃時會有過度收縮且破壞孔隙現象發生。pH越低會使樣本孔洞及孔隙率越大，但低於pH=6.5時會使支架溶解，導致孔隙大小及孔隙率變小。吸水率會隨著支架孔隙大小及孔隙率變小而減少，影響孔隙大小及孔隙率的條件有均質機轉速、pH及加工溫度。在FTIR的分析中確定NaOH在本實驗可為幾丁聚醣支架的硬化劑。在應力-應變分析中得知，當孔隙及孔隙率越小其機械性質越好。在體外酵素分解分析得知，幾丁聚醣為可分解性高分子材料，其分解率隨著時間的增加而提高，分解率到達20%左右趨於平穩。 Three-dimensional chitosan porous scaffolds are used extensively, material’s pore diameter will influence its characterization properties, and biological compatibility directly. Now many persons use PLA to make three-dimensional porous scaffolds and take it conveniently. But PLA can be analyzed for a long time. Nature polymer can not be analyzed for a long time. In this study nature polymer is main material and it is chitosan. In this study we will take chitosan for steadier material and make it porous scaffolds with different pore diameter and porosity, we can change the density of chitosan, control the rotational speed of stirring, and the temperature of process. We will use following methods to test the properties of the sample, use as scanning electron microscope (SEM) to confirm the shape, put sample different pH solution and observe its characterization, use as the standard to test the water content , use as Fourier Transform Infrared Spectroscopy (FTIR) to appraisal the change of profile, use as stress-strain analysis to analyze the mechanical property, use as the enzyme resolve in vitro to test the biological compatibility. The result of experiment shows that when the percent of chitosan solution is 2% and NaOH solution is 5% we can get better shape of the sample. The pore diameter is smaller with the increasing of rotational speed, but when the speed is over 4000rpm the pore diameter and porosity are not different from others. If we change the temperature of process, the result shows that be broken when the temperature to get in 60℃, and the material overexpansion when the temperature to get in 80℃. The pore diameter and porosity will be bigger with the pH value is raising, but steadier is dissolved and the pore diameter is broken when the pH value is 6.5. The water content is decrease with the pore diameter and porosity. We change conditions are the rotational speed, pH value and the temperature of process. The result of FTIR shows that NaOH is hardener with chitosan scaffolds in this study. The result of stress-strain analysis shows that its mechanical property is better when its pore diameter and porosity is increasing. In the enzyme the hardener of chitosan. In the enzyme resolve in vitro analysis shows that chitosan is degradable polymer material and analyzing rate is increasing with time. analyzing rate is about 20%.
顯示於類別:	[化學工程與材料工程學系暨碩士班] 博碩士論文

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