文化大學機構典藏 CCUR:Item 987654321/2714
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    請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/2714


    題名: Testis-specific expression and genomic multiplicity of the rat Rtdpoz genes that encode bipartite TRAF- and POZ/BTB-domain proteins
    作者: Choo, Kong-Bung
    Hsu, Min-Chuan
    Chong, Kowit-Yu
    Huang, Chiu-Jung
    貢獻者: 動科系
    關鍵詞: TDPOZ proteins
    retro-insertions
    testicular expression
    intronless coding sequence
    tissue-specific gene expression
    日期: 2007
    上傳時間: 2009-11-16 11:01:23 (UTC+8)
    摘要: Based on biomformatics analysis, we previously hypothesized the existence of a bipartite TDPOZ protein family members of which carry the TRAF domain (TD) and POZ/BTB [Huang, C.-J., Chen, C.-Y., Chen, H.-H., Tsai, S.-F., Choo, K.-B., 2004. TDPOZ, a family of bipartite annnal and plant proteins that contain the TRAF (TD) and POZ/BTB domains. Gene 324, 117-127.]. Conservation in animals and plants suggests important biological functions for the putative TDPOZ proteins. In this work, we report testis-specific expression of two new Tdpoz members, Rtdpoz-T1 and -T2, of the rat genome; the result clearly indicates that members of the hypothetical gene family are, indeed, expressed. T1 and T2 cDNA sequences were derived by rapid amplification of cDNA ends (RACE). The exons of the genes were determined by queries of the rat genome sequence draft and selectively confirmed in splicing assays. The results indicate that T1 and T2 share a common leader exon indicative of alternative splicing, and that the genes are uninterrupted by introns in their respective coding sequences. Database interrogations also reveal a combined 297 hits of RtdPoz-like sequences oil 7 chromosomes; however, the bulk of the hits (264) and 26 Putative TDPOZ-encoding genes, including T1 and T2, are found in a similar to 2.5 Mb cluster in the Rn2_2148 supercontig on chromosome 2. Our data signify retrotransposition in the generation and expansion of the Rtdpoz repertoire in the rat genuine. We also anticipate spatio-temporal-specific expression of many more TDPOZ members in the rat or other animals and plants. (c) 2006 Elsevier B.V. All rights reserved.
    關聯: GENE Volume: 387 Issue: 1-2 Pages: 141-149
    顯示於類別:[動物科學系 ] 期刊論文

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