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    题名: INHIBITION OF NOTCH SIGNALING PROTECTS MOUSE LUNG AGAINST ZYMOSAN-INDUCED INJURY
    作者: Han, H (Han, Han)
    Gong, G (Gong, Gu)
    Bai, XG (Bai, Xiaoguang)
    Lin, YC (Lin, Yen-Chang)
    Sun, J (Sun, Jing)
    Wang, WY (Wang, Wenyong)
    Zhao, YL (Zhao, Yiling)
    Yang, LF (Yang, Lifang)
    Wang, XX (Wang, Xiaoxia)
    Zhang, ZX (Zhang, Zexin)
    Dong, HL (Dong, Hailong)
    Hou, LC (Hou, Lichao)
    Xiong, LZ (Xiong, Lize)
    贡献者: Grad Inst Biotechnol
    关键词: Zymosan
    acute lung injury
    notch signaling
    inflammation
    日期: 2013-10
    上传时间: 2014-03-03 16:39:40 (UTC+8)
    摘要: Notch signaling, a critical pathway in cell fate determination, is well known to be involved in immune and inflammatory reactions, whereas its role in acute lung injury (ALI) remains unclear. Here, we report that notch signal activity is upregulated in lung tissue harvested from an ALI mouse model (induced by zymosan). We showed that notch signal activity in lung tissue was increased 6 h after zymosan injection and peaked at 24 h. Inhibition of notch signaling by either pre- or post-zymosan treatment with N-[N-(3,5-difluorophenacetyl)-l-alanyl]-(S)-phenylglycine t-butyl ester (DAPT) significantly reduced lung injury, characterized by improvement in lung histopathology, lung permeability (protein concentration in bronchoalveolar lavage fluid and lung wet-to-dry weight ratio), lung inflammation (bronchoalveolar lavage fluid cell count, lung myeloperoxidase, and tumor necrosis factor alpha), and also alleviated systemic inflammation and tissue damage, thus increasing the 7-day survival rate in zymosan-challenged mice. In conclusion, the role of notch signaling is functionally significant in the development of ALI. Inhibition of notch signaling by pretreatment or posttreatment with DAPT likely exerts its effects in part by mediating the expression of proinflammatory and anti-inflammatory cytokines and influencing tissue neutrophil recruitment. These results also imply that notch inhibitors may help attenuate local inflammatory lung damage.
    關聯: SHOCK Volume: 40 Issue: 4 Pages: 312-319 Published: OCT 2013
    显示于类别:[生物科技研究所 ] 期刊論文

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