文化大學機構典藏 CCUR:Item 987654321/26932
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    题名: Inhibitive Effects of Mulberry Leaf-Related Extracts on Cell Adhesion and Inflammatory Response in Human Aortic Endothelial Cells
    作者: Chao, PY (Chao, P.-Y.)
    Lin, KH (Lin, K.-H.)
    Chiu, CC (Chiu, C.-C.)
    Yang, YY (Yang, Y.-Y.)
    Huang, MY (Huang, M.-Y.)
    Yang, CM (Yang, C.-M.)
    贡献者: Dept Nutr & Hlth Sci
    关键词: NF-KAPPA-B
    ALBA L. LEAVES
    PROLIFERATOR-ACTIVATED RECEPTORS
    IN-VITRO ANTIOXIDANT
    HUMAN-LYMPHOCYTES
    DNA-DAMAGE
    PPAR-ALPHA
    TRANSCRIPTION FACTOR
    VITAMIN-C
    FLAVONOIDS
    日期: 2013
    上传时间: 2014-03-03 11:34:30 (UTC+8)
    摘要: Effects of mulberry leaf-related extracts (MLREs) on hydrogen peroxide-induced DNA damage in human lymphocytes and on inflammatory signaling pathways in human aortic endothelial cells (HAECs) were studied. The tested MLREs were rich in flavonols, especially bombyx faces tea (BT) in quercetin and kaempferol. Polyphenols, flavonoids, and anthocyanidin also abounded in BT. The best trolox equivalent antioxidant capacity (TEAC) was generated from the acidic methanolic extracts of BT. Acidic methanolic and water extracts of mulberry leaf tea (MT), mulberry leaf (M), and BT significantly inhibited DNA oxidative damage to lymphocytes based on the comet assay as compared to the H2O2-treated group. TNF-alpha-induced monocyte-endothelial cell adhesion was significantly suppressed by MLREs. Additionally, nuclear factor kappa B (NF-kappa B) expression was significantly reduced by BT and MT. Significant reductions were also observed in both NF-kappa B and activator protein (AP)-1 DNA binding by MLREs. Significant increases in peroxisome proliferator-activated receptor (PPAR) alpha and gamma DNA binding by MLREs were also detected in Mand MT extracts, but no evidence for PPAR alpha DNA binding in 50 mu g/mL MT extract was found. Apparently, MLREs can provide distinct cytoprotective mechanisms that may contribute to its putative beneficial effects on suppressing endothelial responses to cytokines during inflammation.
    關聯: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE Article Number: 267217
    显示于类别:[保健營養學系 ] 期刊論文

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