Albusin B, mass-produced by the Saccharomyces cerevisiae suppression system, enhances lipid utilisation and antioxidant capacity in mice

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Title:	Albusin B, mass-produced by the Saccharomyces cerevisiae suppression system, enhances lipid utilisation and antioxidant capacity in mice
Authors:	Hsieh, YH (Hsieh, Ya-Hui) Wang, HT (Wang, Han-Tsung) Hsu, JT (Hsu, Jih-Tay) Chen, CY (Chen, Ching-Yi)
Contributors:	Dept Anim Sci
Keywords:	albusin B mice lipid utilisation antioxidant capacity anti-atherosclerosis
Date:	2013-08-30
Issue Date:	2014-02-25 13:14:44 (UTC+8)
Abstract:	BackgroundAlbusin B (bacteriocin), isolated from Ruminococcus albus 7 and mass-produced by the Saccharomyces cerevisiae expression system, has previously been shown to have a beneficial effect on lipid metabolism in broiler chickens. The present study was focused on the effect of albusin B on lipid metabolism in mice and the potential of albusin B-expressing yeast product (albusin B) as a food supplement. Forty-five BALB/c male mice at 6weeks of age were each orally administered normal saline (control), yeast (0.125mgkg(-1)) or albusin B (0.125mgkg(-1)) for 14days and then euthanised. ResultsCompared with the control group, albusin B-fed mice exhibited decreased body weight and plasma levels of triglycerides and free fatty acids but increased plasma high-density lipoprotein. Albusin B-fed mice showed higher mRNA expression of fatty acid oxidation in the ileum, heart and liver than control mice. Compared with the control treatment, both yeast and albusin B treatments caused a decrease in mRNA expression of fatty acid synthesis in the heart and liver. Moreover, albusin B suppressed mRNA levels of lipogenesis in the ileum and liver. Albusin B-fed mice exhibited more favourable adenosine triphosphate production and antioxidant capacity in the heart and liver. Albusin B treatment led to a significantly lower respiratory quotient than that of the control, whereas yeast treatment did not. ConclusionThis study demonstrated a beneficial effect of albusin B on lipid utilisation and anti-atherosclerotic and antioxidant capacities in mice. However, more comprehensive studies are required to elucidate the exact mechanism behind the effect of albusin B. (c) 2013 Society of Chemical Industry
Relation:	JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE Volume: 93 Issue: 11 Pages: 2758-2764
Appears in Collections:	[Department of Animal Science] journal articles

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