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| 題名: | Albusin B, mass-produced by the Saccharomyces cerevisiae suppression system, enhances lipid utilisation and antioxidant capacity in mice |
| 作者: | Hsieh, YH (Hsieh, Ya-Hui)
Wang, HT (Wang, Han-Tsung)
Hsu, JT (Hsu, Jih-Tay)
Chen, CY (Chen, Ching-Yi) |
| 貢獻者: | Dept Anim Sci |
| 關鍵詞: | albusin B
mice
lipid
utilisation
antioxidant capacity
anti-atherosclerosis |
| 日期: | 2013-08-30 |
| 上傳時間: | 2014-02-25 13:14:44 (UTC+8) |
| 摘要: | BackgroundAlbusin B (bacteriocin), isolated from Ruminococcus albus 7 and mass-produced by the Saccharomyces cerevisiae expression system, has previously been shown to have a beneficial effect on lipid metabolism in broiler chickens. The present study was focused on the effect of albusin B on lipid metabolism in mice and the potential of albusin B-expressing yeast product (albusin B) as a food supplement. Forty-five BALB/c male mice at 6weeks of age were each orally administered normal saline (control), yeast (0.125mgkg(-1)) or albusin B (0.125mgkg(-1)) for 14days and then euthanised.
ResultsCompared with the control group, albusin B-fed mice exhibited decreased body weight and plasma levels of triglycerides and free fatty acids but increased plasma high-density lipoprotein. Albusin B-fed mice showed higher mRNA expression of fatty acid oxidation in the ileum, heart and liver than control mice. Compared with the control treatment, both yeast and albusin B treatments caused a decrease in mRNA expression of fatty acid synthesis in the heart and liver. Moreover, albusin B suppressed mRNA levels of lipogenesis in the ileum and liver. Albusin B-fed mice exhibited more favourable adenosine triphosphate production and antioxidant capacity in the heart and liver. Albusin B treatment led to a significantly lower respiratory quotient than that of the control, whereas yeast treatment did not.
ConclusionThis study demonstrated a beneficial effect of albusin B on lipid utilisation and anti-atherosclerotic and antioxidant capacities in mice. However, more comprehensive studies are required to elucidate the exact mechanism behind the effect of albusin B. (c) 2013 Society of Chemical Industry |
| 關聯: | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE Volume: 93 Issue: 11 Pages: 2758-2764 |
| 顯示於類別: | [Department of Animal Science] journal articles
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