Moscatilin Induces Apoptosis and Mitotic Catastrophe in Human Esophageal Cancer Cells

文化大學機構典藏 CCUR > 體育運動健康學院 > 運動教練研究所 > 期刊論文 > Item 987654321/26703

請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/26703

題名:	Moscatilin Induces Apoptosis and Mitotic Catastrophe in Human Esophageal Cancer Cells
作者:	Chen, CA (Chen, Chien-An) Chen, CC (Chen, Chien-Chih) Shen, CC (Shen, Chien-Chang) Chang, HH (Chang, Hen-Hong) Chen, YJ (Chen, Yu-Jen)
貢獻者:	Grad Inst Sport Coaching Sci
關鍵詞:	esophageal cancer moscatilin polyploidization sub-G1
日期:	2013-10-01
上傳時間:	2014-02-24 15:21:11 (UTC+8)
摘要:	Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, has been shown to possess anticancer activity. We examined the effect of moscatilin on human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) cells and its possible mechanisms. Moscatilin suppressed the growth of both the histological cell lines in a dose- and time-dependent manner. Morphological changes indicative of apoptosis and mitotic catastrophe were observed following moscatilin treatment. The population of cells in the sub-G1 phase and polyploidy phase significantly increased after treatment. Immunofluorescence revealed multipolar mitosis and subsequent multinucleation in moscatilin-treated cells, indicating the development of mitotic catastrophe. Western blot showed a marked increase in expressions of polo-like kinase 1 and cyclin B1 after exposure to moscatilin. In conclusion, moscatilin inhibits growth and induces apoptosis and mitotic catastrophe in human esophageal SCC- and ADC-derived cell lines, indicating that moscatilin has broad potential against esophageal cancer.
關聯:	JOURNAL OF MEDICINAL FOOD Volume: 16 Issue: 10 Pages: 869-877
顯示於類別:	[運動教練研究所] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	472	檢視/開啟

檢視Licence

在CCUR中所有的資料項目都受到原著作權保護.

資料載入中.....