Loading...
|
Please use this identifier to cite or link to this item:
https://irlib.pccu.edu.tw/handle/987654321/2635
|
| Title: | Cytotoxic polyketides containing tetramic acid moieties isolated from the fungus Myceliophthora thermophila: Elucidation of the relationship between cytotoxicity and stereoconfiguration |
| Authors: | Yang, Yu-Liang
Lu, Chun-Ping
Chen, Mao-Yen
Chen, Kuei-Yu
Wu, Yang-Chang
Wu, Shih-Hsiung |
| Contributors: | 生科系 |
| Keywords: | configuration determination
cytotoxicity
myceliothermophins
polyketides
structure elucidation |
| Date: | 2007 |
| Issue Date: | 2009-11-11 10:58:35 (UTC+8) |
| Abstract: | Five new polyketides that contain tetramic acids, myceliothermophins A-E, were isolated from the thermophilic fungus Myceliophthora thermophila. Two sets of 5-alkyl-5-hydroxyl (or 5-methoxyl)-1H-pyrrol-2(5H)-one diastereomers, myceliothermophins A/B and C/D, were separated as pure compounds by using silica-gel column chromatography and recycling reverse-phase high-performance liquid chromatography (RP-HPLC). The relative configurations of the chiral centers in 5-alkyl-5-hydroxyl (or 5-methoxyl)-1H-pyrrol-2(5H)-one moieties were deduced from NOESY correlations. In the cytotoxic assay, the 5-(2-methylpropyldiene)-1 H-pyrrol-2(5H)-one analogue (myceliothermophin E) exhibited inhibition against four cancer cell lines. In addition, the significant inhibitory effect of myceliothermophins A and C and the inactivity of myceliothermophins B and D revealed the importance of the relative configurations of 5-alkyl-5-hydroxyl (or 5-methoxyl)-1H-pyrrol-2(5H)-one moieties on their cytotoxicity potency against cancer cells. |
| Relation: | CHEMISTRY-A EUROPEAN JOURNAL Volume: 13 Issue: 24 Pages: 6985-6991 |
| Appears in Collections: | [生命科學系] 期刊論文
|
Files in This Item:
There are no files associated with this item.
|
All items in CCUR are protected by copyright, with all rights reserved.
|
