Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni

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题名:	Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni
作者:	Chen, Yu-Jen Cheng, Po-Ching Lin, Ching-Nan Liao, Hui-Fen Chen, Yu-Yawn Chen, Chin-Chu Lee, Kin-Mu
贡献者:	體育系
关键词:	Antrodia camphorata polysaccharide immunomodulation dendritic cells Schistosoma mansoni
日期:	2008
上传时间:	2009-11-06 15:00:50 (UTC+8)
摘要:	Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evaluating cytokine expression; on immunomodulation, by evaluating spleen cells; and on Schistosoma mansoni infection in mice. The induction of high levels of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) mRNA was detected in BALB/c mice after 2, 4, and 6 weeks of oral AC-PS administration. After 6 weeks of oral AC-PS administration to the BALB/c mice, the number of splenic dendritic cells, macrophages, and the surface expression of CD8 alpha(+) and major histocompatibility class II I-A/I-E on dendritic cells increased. The CD4(+)/CD8(+) ratio and number of B cells among splenocytes were also augmented. By using a disease model of parasitic infection, we found that AC-PS treatment inhibited S. mansoni infection in BALB/c mice. AC-PS appears to modulate the immune system of mice and has potential for preventing S. mansoni infection. (c) 2007 Elsevier B.V. All rights reserved.
關聯:	INTERNATIONAL IMMUNOPHARMACOLOGY Volume: 8 Issue: 3 Pages: 458-467
显示于类别:	[體育學系] 期刊論文

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