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https://irlib.pccu.edu.tw/handle/987654321/24273
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| 題名: | Immunomodulatory Effects of Xylooligosaccharides |
| 作者: | Chen, HH (Chen, Hua Han)
Chen, YK (Chen, Yu Kuo)
Chang, HC (Chang, Hung Chia)
Lin, SY (Lin, Su Yi) |
| 貢獻者: | Dept Appl Sci Living |
| 關鍵詞: | xylooligosaccharides
immunomodulatory
anti-inflammatory
TUMOR-NECROSIS-FACTOR
KAPPA-B ACTIVATION
NITRIC-OXIDE
INFLAMMATORY MEDIATORS
OLIGOSACCHARIDES
MACROPHAGES
PATHOPHYSIOLOGY
MECHANISMS
EXPRESSION
CYTOKINES |
| 日期: | 2012-03 |
| 上傳時間: | 2013-02-22 14:20:53 (UTC+8) |
| 摘要: | Xylooligosaccharides (XOs) are considered as food ingredients, and exhibit the prebiotic effects related to gut modulation. However, no related research is available to explain their immunomodulatory effects. This report elucidated their immunomodulatory effects through the variations of proinflammatory mediators in vitro. We found that XOs (0.1-100 mu g/mL) induced tumor necrosis factor alpha (TNF-alpha), IL-1 beta IL-6 and nitric oxide (NO) production in un-stimulated macrophages, RAW264.7 cells. Furthermore, pre- and post-treated XOs (0.1-100 mu g/mL) dose-dependently suppressed TNF-alpha, IL-1 beta IL-6 and NO production and induced IL-10 production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells with-out exerting cytotoxicity. Of note is that prostaglandin E-2 (PGE(2)) production didn't change significantly through the XOs treatment. These data demonstrate that XOs potently down-regulates the LPS-induced inflammatory response. The in vitro assessment of inflammatory mediators should be useful in further characterization of the effects of XOs on immunomodulation. |
| 關聯: | FOOD SCIENCE AND TECHNOLOGY RESEARCH 卷: 18 期: 2 頁數: 195-199 |
| 顯示於類別: | [生活應用科學系暨生活應用科學研究所] 期刊論文
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