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    题名: Immunomodulatory effects of feruloylated oligosaccharides from rice bran
    作者: Fang, HY (Fang, Hsin-Yu)
    Chen, YK (Chen, Yu-Kuo)
    Chen, HH (Chen, Hua-Han)
    Lin, SY (Lin, Su-Yi)
    Fang, YT (Fang, Yi-Ting)
    贡献者: Dept Appl Sci Living
    关键词: Feruloylated oligosaccharides
    Immunomodulatory
    Anti-inflammatory
    Therapeutic
    日期: 2012-09
    上传时间: 2013-02-19 16:19:00 (UTC+8)
    摘要: Feruloylated oligosaccharides (FOs), the ferulic acid ester of oligosaccharides, can be released either by the enzymatic or mild acid hydrolysis of arabinoxylans present in cereal bran, and are usually considered as natural antioxidants. However, no related research is available to explain their immunomodulatory effects. This report elucidated their immunomodulatory effects through the variations of pro-inflammatory mediators in vitro. FOs were obtained from the mild acid hydrolysis of rice bran. We found that FOs (0.1-100 mu g/ml) induced tumour necrosis factor alpha (TNF-alpha), IL-1 beta, IL-6, nitric oxide (NO) and PGE(2) production in unstimulated macrophages, RAW264.7 cells. Furthermore, pre- and post-treated FOs (0.1-100 mu g/ml) dose-dependently suppressed TNF-alpha, IL-1 beta, IL-6 and NO production, and induced IL-10 production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells without exerting cytotoxicity. As a result anti-inflammatory and therapeutic activities were revealed. It is noteworthy that prostaglandin E-2 (PGE(2)) production was significantly suppressed at an FO level of 100 mu g/ml. The in vitro assessment of inflammatory mediators should be useful in further characterising the effects of FOs on immunomodulation. Moreover, it will create the economical value of rice bran, which has long been considered as conventional agricultural wastes. (C) 2012 Elsevier Ltd. All rights reserved.
    關聯: FOOD CHEMISTRY 卷: 134 期: 2 頁數: 836-840
    显示于类别:[生活應用科學系暨生活應用科學研究所] 期刊論文

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