Total synthesis and antioxidative activity of magnolamide from Magnolia coco

CCUR > College of Natural Science and Engineering > College of Science > Department of Chemistry & Graduate Institute of Applied Chemistry > journal articles > Item 987654321/2414

Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/2414

Title:	Total synthesis and antioxidative activity of magnolamide from Magnolia coco
Authors:	Chiou, W.F.;Shen, C.C.;Yu, H.J.;Chiang, C.H.;Chen, C.C.;Chang, W.Y.;Don, M.J.
Contributors:	化學系
Date:	2005
Issue Date:	2009-10-30 14:24:49 (UTC+8)
Abstract:	A simple total synthesis of naturally occurring magnolamide, N-[4-(2-formyl-5-hydroxymethylpyrrol-1-yl)butyl]-3-(4-hydroxy-3-methoxyphenyl)-2-propenamide, from pyrrole-2,5-dicarbaldehyde was performed in six steps and its antioxidant activity was compared with probucol and resveratrol. Results showed that magnolamide markedly inhibited CuSO4-induced oxidation of human low-density lipoprotein (IC50 = 9.7 μ M) with similar activity to probucol and resveratrol.
Relation:	HETEROCYCLES v.65 n.5 Pages: 1215-1220
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

Files in This Item:

There are no files associated with this item.