Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa

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题名:	Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa
作者:	Ueng, Y.F.;Yu, H.J.;Lee, C.H.;Peng, C.;Jan, W.C.;Ho, L.K.;Chen, C.F.;Don, M.J.
贡献者:	化學系
日期:	2005
上传时间:	2009-10-30 14:23:14 (UTC+8)
摘要:	Rutaecarpine is a quinazolinocarboline alkaloid of the medicinal herb Evodia rutaecarpa and shows a variety of pharmacological effects. Four oxidation metabolites of rutaecarpine were prepared from 3-methylcholanthrene-treated rat liver microsomes. These metabolites had an [M + H](+) ion at m/z 304. The structures of metabolites were identified by comparison of their liquid chromatograms and mass, absorbance, and H-1 NMR spectra with those of synthetic standards. Rutaecarpine was metabolized by microsomal enzymes to form 3, 10, 11-, and 12-hydroxyrutaecarpine. The formation of 10-hydroxyrutaecarpine was highly induced by a cytochrome P450 1A inducer, 3-methylcholanthrene. © 2005 Elsevier B.V. All rights reserved.
關聯:	JOURNAL OF CHROMATOGRAPHY A v.1076 n.1-2 Pages: 103-109
显示于类别:	[化學系所] 期刊論文

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