文化大學機構典藏 CCUR:Item 987654321/2407
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/2407


    题名: DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum
    作者: Kuo, L.M.Y.;Chen, K.Y.;Hwang, S.Y.;Chen, J.L.;Liu, Y.Y.;Liaw, C.C.;Ye, P.H.;Chou, C.J.;Shen, C.C.;Kuo, Y.H.
    贡献者: 生命科學系
    日期: 2005
    上传时间: 2009-10-30 14:07:43 (UTC+8)
    摘要: Recently, we found that the MeOH extract of Penicillium oxalicum showed inhibitory activity towards DNA topoisomerase I. Subsequently, ergosterol peroxide, ergosterol, palmitoleic acid, and linoleic acid were isolated from the cultured mycelia of A oxalicum. The structural determinations were based on physical and spectral analyses. Biological evaluation revealed that ergosterol peroxide inhibited the relaxation of supercoiled DNA (pBR322) induced by DNA topoisomerase I, and also showed marginal, selective cytotoxic activity against human colon tumor cells [COLO-205 (ED50) = 8.56 mug/mL].
    關聯: PLANTA MEDICA v.71 n.1 Pages: 77-79
    显示于类别:[生命科學系] 期刊論文

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