文化大學機構典藏 CCUR:Item 987654321/24057
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 47184/51050 (92%)
造访人次 : 13959432      在线人数 : 269
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CCUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/24057


    题名: Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese
    作者: Hsu, LA (Hsu, Lung-An)[ 2 ]
    Ko, YL (Ko, Yu-Lin)
    Teng, MS (Teng, Ming-Sheng)
    Wu, SM (Wu, Semon)
    Chou, HH (Chou, Hsin-Hua)
    Chang, PY (Chang, Pi-Yueh)
    Chang, HH (Chang, Hsien-Hsun)
    贡献者: Dept Life Sci
    关键词: C-reactive protein
    Hepatic nuclear factor-1 alpha
    Polymorphism
    Obesity
    日期: 2011-04-11
    上传时间: 2013-01-24 11:31:31 (UTC+8)
    摘要: Background: The level of C-reactive protein (CRP), an inflammatory biomarker that predicts future cardiovascular events, is a heritable trait that has been associated with variants of CRP and hepatic nuclear factor-1 alpha (HNF1A) genes. Our aim was to test the statistical association between HNF1A genotypes/haplotypes and serum CRP level in Taiwanese.

    Methods: A sample population of 617 Taiwanese subjects (all Han-Chinese origin) was enrolled. Five HNF1A single nucleotide polymorphisms (SNPs) rs1920792, rs1169288, rs7310409, rs2464196, rs1169310 were genotyped and analyzed.

    Results: After adjusting for clinical covariates, minor alleles of all the 5 study SNPs were associated with decreased CRP level (P=0.0078, P=0.0107, P=0.0006, P=0.0004 and P=0.0003, respectively). A common haplotype (TGATA) tagged by the minor alleles of study SNPs was associated with significantly decreased CRP level (P=0.0112). Subgroup analysis revealed that the association between HNF1A genotypes and CRP level occurred only in non-obese subjects.

    Conclusions: HNF1A polymorphisms are independently associated with CRP level in Taiwanese. Further, HNF1A genotypes interact with obesity to set CRP level, revealing that genetic determinants for CRP level may be different between obese and non-obese individuals. (C) 2011 Elsevier B.V. All rights reserved.
    關聯: CLINICA CHIMICA ACTA 卷: 412 期: 9-10 頁數: 725-729
    显示于类别:[生命科學系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML425检视/开启


    检视Licence

    在CCUR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈