Intensity modulated radiotherapy for elderly bladder cancer patients

CCUR > College of Kinesiology and Health > Graduate Institute of Sport Coaching Science > journal articles > Item 987654321/24022

Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/24022

Title:	Intensity modulated radiotherapy for elderly bladder cancer patients
Authors:	Hsieh, CH (Hsieh, Chen-Hsi) Chung, SD (Chung, Shiu-Dong) Chan, PH (Chan, Pei-Hui) Lai, SK (Lai, Siu-Kai) Chang, HC (Chang, Hsiao-Chun) Hsiao, CH (Hsiao, Chi-Huang) Wu, LJ (Wu, Le-Jung) Chong, NS (Chong, Ngot-Swan) Chen, YJ (Chen, Yu-Jen) Wang, LY (Wang, Li-Ying) Hsieh, YP (Hsieh, Yen-Ping) Shueng, PW (Shueng, Pei-Wei)
Contributors:	Grad Inst Sport Coaching Sci
Keywords:	Bladder cancer Concurrent chemoradiation Helical tomotherapy Intensity modulated radiation therapy
Date:	2011-06-16
Issue Date:	2013-01-17 13:53:13 (UTC+8)
Abstract:	Background: To review our experience and evaluate treatment planning using intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) for the treatment of elderly patients with bladder cancer. Methods: From November 2006 through November 2009, we enrolled 19 elderly patients with histologically confirmed bladder cancer, 9 in the IMRT and 10 in the HT group. The patients received 64.8 Gy to the bladder with or without concurrent chemotherapy. Conventional 4-field "box" pelvic radiation therapy (2DRT) plans were generated for comparison. Results: The median patient age was 80 years old (range, 65-90 years old). The median survival was 21 months (5 to 26 months). The actuarial 2-year overall survival (OS) for the IMRT vs. the HT group was 26.3% vs .37.5%, respectively; the corresponding values for disease-free survival were 58.3% vs. 83.3%, respectively; for locoregional progression-free survival (LRPFS), the values were 87.5% vs. 83.3%, respectively; and for metastases-free survival, the values were 66.7% vs. 60.0%, respectively. The 2-year OS rates for T1, 2 vs. T3, 4 were 66.7% vs. 35.4%, respectively (p = 0.046). The 2-year OS rate was poor for those whose RT completion time greater than 8 weeks when compared with the RT completed within 8 wks (37.9% vs. 0%, p = 0.004). Conclusion: IMRT and HT provide good LRPFS with tolerable toxicity for elderly patients with invasive bladder cancer. IMRT and HT dosimetry and organ sparing capability were superior to that of 2DRT, and HT provides better sparing ability than IMRT. The T category and the RT completion time influence OS rate.
Relation:	RADIATION ONCOLOGY Volume: 6 Article Number: 75
Appears in Collections:	[Graduate Institute of Sport Coaching Science ] journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	423	View/Open

View Licence

Loading...