Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose

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Title:	Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose
Authors:	Lin, Yung-Kai Chen, Ko-Hua Ou, Keng-Liang Liu, Min
Contributors:	生命科學系
Keywords:	RAT MICROBIAL CELLULOSE COLLAGEN FIBROBLASTS HYALURONAN PRODUCTS INJURY REPAIR
Date:	2011-09
Issue Date:	2012-09-07 14:31:28 (UTC+8)
Abstract:	To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.
Relation:	Source: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS Volume: 26 Issue: 5 Pages: 508-518
Appears in Collections:	[Department of Biology ] journal articles

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