文化大學機構典藏 CCUR:Item 987654321/22933
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    题名: Molecular evolution of a family of resistance gene analogs of nucleotide-binding site sequences in Solanum lycopersicum
    作者: Liao, Pei-Chun)2
    Lin, KH (Lin, Kuan-Hung)3
    Ko, CL (Ko, Chin-Ling)3
    Hwang, SY (Hwang, Shih-Ying
    贡献者: 生命科學系
    关键词: SELECTION
    NB-ARC DOMAIN
    PLANT IMMUNITY GENES
    DISEASE-RESISTANCE
    R-GENE
    ARABIDOPSIS-THALIANA
    NATURAL-POPULATIONS
    ENCODING GENES
    PROTEINS
    DIVERSITY
    日期: 2011-10
    上传时间: 2012-09-06 15:36:35 (UTC+8)
    摘要: Nucleotide-binding site-leucine-rich repeats (NBS-LRR) gene families are one of the major plant resistance genes. Genomic NBS evolution was studied in many plant species for diverse arrays of NBS gene families. In this study, we focused on one family of NBS sequences in an attempt to understand how closely related NBS sequences evolved in the light of selection in domesticated plant species. A phylogenetic analysis revealed five major clades (A-E) and five subclades (A1-A5) within clade A of cloned NBS sequences. Positive selection was only detected in newly evolved NBS lineages in subclades of clade A. Positively selected codon sites were found among NBS sequences of clade A. A sliding-window analysis revealed that regions with Ka/Ks ratios of > 1 were in the inter-motifs when paired clades were compared, but regions with Ka/Ks ratios of > 1 were found across NBS sequences when subclades of clade A were compared. Our results based on a family of closely related NBS sequences showed that positive selection was first exerted on specific lineages across all NBS sequences after selective constraints. Subsequently, sequences with mutations in commonly conserved motifs were scrutinized by purifying selection. In the long term, conserved high frequency alleles in commonly conserved motifs and changes in inter-motifs were maintained in the investigated family of NBS sequences. Moreover, codons identified to be under positive selection in the inter-motifs were mainly located in regions involved in functions of ATP binding or hydrolysis.
    關聯: Source: GENETICA Volume: 139 Issue: 10 Pages: 1229-1240
    显示于类别:[生命科學系] 期刊論文

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